You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RPS6KB1
Ribosomal protein S6 kinase beta-1

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225577
  • ENSP00000225577
  • ENSG00000108443
  • ENST00000393021
  • ENSP00000376744
  • ENST00000406116
  • ENSP00000384335
  • ENST00000443572
  • ENSP00000441993

Symbol
  • STK14A
  • S6K
  • PS6K
  • S6K1
  • STK14A
  • p70-S6K
  • p70 S6KA
  • p70-alpha
  • S6K-beta-1
  • p70(S6K)-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
hub protein
1
kinase
1
biological process
0.99
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2252.09   (req: < 5)
Gene RIFs: 273   (req: <= 3)
Antibodies: 2421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2252.09   (req: >= 5)
Gene RIFs: 273   (req: > 3)
Antibodies: 2421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 764
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0