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Tbio
GCSH
Glycine cleavage system H protein, mitochondrial

Protein Summary
Description
The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315467
  • ENSP00000319531
  • ENSG00000140905

Symbol
  • GCE
  • NKH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.87
histone modification site profile
0.85
virus perturbation
0.79
tissue sample
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.87   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.87   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
LIAS
Tbio
Family:  Enzyme
Novelty:  0.01269062
p_int:  0.999546541
p_ni:  1.1e-8
p_wrong:  0.000453448
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
GLDC
Tbio
Family:  Enzyme
Novelty:  0.00900467
p_int:  0.997803474
p_ni:  0.002196526
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MGME1
Tbio
Family:  Enzyme
Novelty:  0.05284418
p_int:  0.959446028
p_ni:  0.040553972
Data Source:  BioPlex
AMT
Tbio
Family:  Enzyme
Novelty:  0.00796968
Score:  0.999
Data Source:  Reactome,STRINGDB
LIPT2
Tbio
Family:  Enzyme
Novelty:  0.31022396
Score:  0.993
Data Source:  STRINGDB
LIPT1
Tdark
Family:  Enzyme
Novelty:  0.0546324
Score:  0.992
Data Source:  STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.99
Data Source:  Reactome,STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.98
Data Source:  Reactome,STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.98
Data Source:  STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Glycine degradation (R-HSA-6783984)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glycine degradation
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
88.3
glycine measurement
4
2
4
86.7
amino acid measurement
2
2
2
69.6
mean corpuscular hemoglobin concentration
1
1
1
64.9
protein measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
88.3
glycine measurement
4
86.7
amino acid measurement
2
69.6
mean corpuscular hemoglobin concentration
1
64.9
protein measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine cleavage system protein H
VGNC:9036
468042
Mouse
MGI:1915383
68133
Rat
RGD:619946
171133
Dog
glycine cleavage system protein H
VGNC:53389
479633
Horse
glycine cleavage system protein H
VGNC:51193
100629755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine cleavage system protein H
Mouse
Rat
Dog
glycine cleavage system protein H
Horse
glycine cleavage system protein H
Publication Statistics
PubMed Score 47.87
PubMed score by year
PubTator Score 28.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title