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Tchem
GLRA2
Glycine receptor subunit alpha-2

Protein Classes
Protein Summary
Description
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218075
  • ENSP00000218075
  • ENSG00000101958
  • ENST00000355020
  • ENSP00000347123
  • ENST00000443437
  • ENSP00000387756

Symbol
  • GLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.96
protein domain
0.92
ligand (chemical)
0.72
trait
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.1   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.1   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine receptor alpha 2
VGNC:2718
465502
Macaque
glycine receptor alpha 2
711926
Mouse
MGI:95748
237213
Rat
RGD:2705
24397
Dog
glycine receptor alpha 2
VGNC:41269
491746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine receptor alpha 2
Macaque
glycine receptor alpha 2
Mouse
Rat
Dog
glycine receptor alpha 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23416-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (158)
1 – 10 of 158
MARCH6
Tbio
Family: Enzyme
Novelty: 0.01818691
p_int: 0.999632772
p_ni: 0.000029046
p_wrong: 0.000338183
Score: 0.189
Data Source: BioPlex,STRINGDB
CNNM1
Tdark
Novelty: 0.11053515
p_int: 0.994623723
p_ni: 0.005376132
p_wrong: 1.45e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.974301505
p_ni: 0.025698495
Data Source: BioPlex
KCTD2
Tdark
Novelty: 0.42992811
p_int: 0.970626399
p_ni: 0.002402264
p_wrong: 0.026971337
Score: 0.416
Data Source: BioPlex,STRINGDB
LRP12
Tbio
Novelty: 0.11426952
p_int: 0.952912565
p_ni: 0.045160088
p_wrong: 0.001927347
Score: 0.198
Data Source: BioPlex,STRINGDB
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.942489674
p_ni: 0.057367038
p_wrong: 0.000143288
Data Source: BioPlex
TMEM87A
Tdark
Novelty: 0.33614983
p_int: 0.942269602
p_ni: 0.057726015
p_wrong: 0.000004383
Score: 0.183
Data Source: BioPlex,STRINGDB
BSCL2
Tbio
Novelty: 0.00483959
p_int: 0.938823902
p_ni: 0.061176096
p_wrong: 2e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
TF
Tbio
Novelty: 0.00231826
p_int: 0.93658525
p_ni: 0.06341475
Data Source: BioPlex
PKD2
Tchem
Family: IC
Novelty: 0.00305329
p_int: 0.923507319
p_ni: 0.076492679
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  33.10

PubMed score by year
PubTator Score  20.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer