Tbio ANOS1 Anosmin-1

Protein Summary

Description

Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P23352
• B2RPF8

Gene Name

• ANOS1

Ensembl ID

• ENST00000262648
• ENSP00000262648
• ENSG00000011201

Symbol

• ADMLX
• KAL
• KAL1
• KALIG1
• HH1
• HHA
• KAL
• KMS
• KAL1
• ADMLX
• WFDC19
• KALIG-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.67
biological term	0.57
microRNA	0.54
cell line	0.53
disease	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.29   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.29   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0