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Tbio
ANOS1
Anosmin-1

Protein Summary
Description
Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262648
  • ENSP00000262648
  • ENSG00000011201

Symbol
  • ADMLX
  • KAL
  • KAL1
  • KALIG1
  • HH1
  • HHA
  • KAL
  • KMS
  • KAL1
  • ADMLX
  • WFDC19
  • KALIG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
biological term
0.57
microRNA
0.54
cell line
0.53
disease
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.75   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.75   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
FGFR1 ligand binding and activation (R-HSA-190242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR1 ligand binding and activation
Reactome
FGFR1c ligand binding and activation
Reactome
Negative regulation of FGFR1 signaling
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
FGFR1 ligand binding and activation
FGFR1c ligand binding and activation
Negative regulation of FGFR1 signaling
Signal Transduction
Signaling by FGFR
Protein-Protein Interactions (72)
1 – 10 of 72
FGF2
Tchem
Novelty: 0.00009754
Score: 0.946
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00057077
Score: 0.928
Data Source: STRINGDB
FGF1
Tchem
Novelty: 0.00060955
Score: 0.917
Data Source: STRINGDB
FGF4
Tbio
Novelty: 0.00241958
Score: 0.904
Data Source: STRINGDB
FGF6
Tbio
Novelty: 0.02650664
Score: 0.902
Data Source: STRINGDB
FGF9
Tbio
Novelty: 0.00453388
Score: 0.901
Data Source: STRINGDB
FGF20
Tbio
Novelty: 0.01669193
Score: 0.901
Data Source: STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00068893
Score: 0.877
Data Source: Reactome,STRINGDB
PROKR2
Tchem
Family: GPCR
Novelty: 0.01637311
Score: 0.838
Data Source: STRINGDB
PROK2
Tbio
Novelty: 0.00558025
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score  429.75

PubMed score by year
PubTator Score  237.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer