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Tbio
HRC
Sarcoplasmic reticulum histidine-rich calcium-binding protein

Protein Summary
Description
May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252825
  • ENSP00000252825
  • ENSG00000130528

Symbol
  • HCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
cell type or tissue
0.68
cellular component
0.61
PubMedID
0.6
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.17   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.17   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
ZNF101
Tdark
Family:  TF
Novelty:  0.27004566
p_int:  0.999976216
p_ni:  0.000023784
Score:  0.282
Data Source:  BioPlex,STRINGDB
ZNF430
Tdark
Family:  TF
Novelty:  3.98895047
p_int:  0.99920153
p_ni:  0.000796934
p_wrong:  0.000001535
Score:  0.332
Data Source:  BioPlex,STRINGDB
ZNF791
Tdark
Family:  TF
Novelty:  1.12195103
p_int:  0.987478736
p_ni:  0.011168852
p_wrong:  0.001352412
Score:  0.54
Data Source:  BioPlex,STRINGDB
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.80252961
p_ni:  0.19747039
Score:  0.161
Data Source:  BioPlex,STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.947
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.921
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.916
Data Source:  STRINGDB
PCSK9
Tclin
Family:  Enzyme
Novelty:  0.00030553
Score:  0.912
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.912
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
67.7
body mass index
1
1
1
31.4
heel bone mineral density
1
1
1
31.4
electrocardiography
1
1
3
30.1
body height
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
67.7
body mass index
1
31.4
heel bone mineral density
1
31.4
electrocardiography
3
30.1
body height
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidine rich calcium binding protein
VGNC:2353
456413
Macaque
histidine rich calcium binding protein
718647
Mouse
MGI:96226
15464
Rat
RGD:727864
292905
Dog
histidine rich calcium binding protein
VGNC:41783
484386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidine rich calcium binding protein
Macaque
histidine rich calcium binding protein
Mouse
Rat
Dog
histidine rich calcium binding protein
Publication Statistics
PubMed Score 203.17
PubMed score by year
PubTator Score 54.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title