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Tchem
PPIB
Peptidyl-prolyl cis-trans isomerase B

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300026
  • ENSP00000300026
  • ENSG00000166794

Symbol
  • CYPB
  • B
  • OI9
  • CYPB
  • SCYLP
  • CYP-S1
  • HEL-S-39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
disease perturbation
0.96
cellular component
0.86
kinase perturbation
0.84
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.41   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 449   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.41   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ciclosporin
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
21.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase B
VGNC:6585
747801
Mouse
MGI:97750
19035
Rat
RGD:620312
64367
Dog
peptidylprolyl isomerase B
VGNC:44849
478337
Horse
peptidylprolyl isomerase B
VGNC:21728
100066834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase B
Mouse
Rat
Dog
peptidylprolyl isomerase B
Horse
peptidylprolyl isomerase B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23284-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (348)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (191)
1 – 10 of 191
P3H1
Tbio
Family: Enzyme
Novelty: 0.02067711
Score: 0.995
Data Source: Reactome,STRINGDB
CRTAP
Tbio
Novelty: 0.02380647
Score: 0.995
Data Source: Reactome,STRINGDB
P4HB
Tbio
Family: Enzyme
Novelty: 0.00107905
Score: 0.986
Data Source: STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.982
Data Source: STRINGDB
SERPINH1
Tbio
Novelty: 0.00106715
Score: 0.959
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.952
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.952
Data Source: STRINGDB
FKBP2
Tbio
Family: Enzyme
Novelty: 0.00796637
Score: 0.951
Data Source: STRINGDB
PDIA3
Tbio
Family: Enzyme
Novelty: 0.00285939
Score: 0.947
Data Source: STRINGDB
P3H2
Tbio
Family: Enzyme
Novelty: 0.04237396
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  297.41

PubMed score by year
PubTator Score  92.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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