You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CA6
Carbonic anhydrase 6

Protein Summary
Description
Reversible hydration of carbon dioxide. Its role in saliva is unknown. The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377436
  • ENSP00000366654
  • ENSG00000131686
  • ENST00000377442
  • ENSP00000366661
  • ENST00000377443
  • ENSP00000366662

Symbol
  • CA-VI
  • GUSTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
protein domain
0.58
hub protein
0.53
cell line
0.5
cellular component
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 6
VGNC:9850
457915
Macaque
carbonic anhydrase 6
709540
Mouse
MGI:1333786
12353
Rat
RGD:70516
298657
Dog
carbonic anhydrase 6
VGNC:38614
403503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 6
Macaque
carbonic anhydrase 6
Mouse
Rat
Dog
carbonic anhydrase 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23280-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (62)
1 – 10 of 62
IMMP1L
Tbio
Family: Enzyme
Novelty: 0.16680031
p_int: 0.999818441
p_ni: 0.000006875
p_wrong: 0.000174684
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.996660743
p_ni: 1.47e-7
p_wrong: 0.00333911
Score: 0.214
Data Source: BioPlex,STRINGDB
DCAF6
Tbio
Novelty: 0.01269552
p_int: 0.99624259
p_ni: 0.00375741
Data Source: BioPlex
RHOBTB3
Tbio
Novelty: 0.09149494
p_int: 0.995268753
p_ni: 0.004730619
p_wrong: 6.28e-7
Data Source: BioPlex
PLXNA2
Tbio
Novelty: 0.01765957
p_int: 0.968383279
p_ni: 0.03161651
p_wrong: 2.11e-7
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.947034772
p_ni: 0.052965228
Score: 0.206
Data Source: BioPlex,STRINGDB
PTCD2
Tdark
Novelty: 0.23529342
p_int: 0.897044179
p_ni: 0.102953534
p_wrong: 0.000002286
Data Source: BioPlex
NPC2
Tbio
Novelty: 0.00342898
p_int: 0.884832802
p_ni: 0.115167017
p_wrong: 1.81e-7
Data Source: BioPlex
LAMB2
Tbio
Novelty: 0.07966931
p_int: 0.834284754
p_ni: 0.165715246
Data Source: BioPlex
PLXNA3
Tbio
Novelty: 0.02016528
p_int: 0.831823608
p_ni: 0.168176392
Data Source: BioPlex
Publication Statistics
PubMed Score  351.95

PubMed score by year
PubTator Score  138.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer