Protein Summary
Reversible hydration of carbon dioxide. Its role in saliva is unknown. The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
- ENST00000377436
- ENSP00000366654
- ENSG00000131686
- ENST00000377442
- ENSP00000366661
- ENST00000377443
- ENSP00000366662
- CA-VI
- GUSTIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
protein domain | 0.58 | ||
hub protein | 0.53 | ||
cell line | 0.5 | ||
cellular component | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.77 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 331 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.77 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 331 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 221
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
Active Ligands (221)
Protein-Protein Interactions (62)
IMMP1L
Family: Enzyme
Novelty: 0.16680031
p_int: 0.999818441
p_ni: 0.000006875
p_wrong: 0.000174684
Data Source: BioPlex
FRMD1
Novelty: 0.96833141
p_int: 0.996660743
p_ni: 1.47e-7
p_wrong: 0.00333911
Score: 0.214
Data Source: BioPlex,STRINGDB
RHOBTB3
Novelty: 0.09149494
p_int: 0.995268753
p_ni: 0.004730619
p_wrong: 6.28e-7
Data Source: BioPlex
PLXNA2
Novelty: 0.01765957
p_int: 0.968383279
p_ni: 0.03161651
p_wrong: 2.11e-7
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.947034772
p_ni: 0.052965228
Score: 0.206
Data Source: BioPlex,STRINGDB
PTCD2
Novelty: 0.23529342
p_int: 0.897044179
p_ni: 0.102953534
p_wrong: 0.000002286
Data Source: BioPlex
NPC2
Novelty: 0.00342898
p_int: 0.884832802
p_ni: 0.115167017
p_wrong: 1.81e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 3 | 3 | 91.8 | |||||
platelet crit | 2 | 2 | 2 | 86.4 | |||||
myeloid white cell count | 2 | 2 | 2 | 82.2 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 49.5 | |||||
basophil count | 2 | 2 | 2 | 40.7 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 91.8 | |||||
platelet crit | 2 | 86.4 | |||||
myeloid white cell count | 2 | 82.2 | |||||
lymphocyte percentage of leukocytes | 1 | 49.5 | |||||
basophil count | 2 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 6 | VGNC:9850 | 457915 | |||||
Macaque | carbonic anhydrase 6 | 709540 | ||||||
Mouse | MGI:1333786 | 12353 | ||||||
Rat | RGD:70516 | 298657 | ||||||
Dog | carbonic anhydrase 6 | VGNC:38614 | 403503 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 6 | |||||
Macaque | carbonic anhydrase 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 6 | |||||
Publication Statistics
PubMed Score 355.77
PubMed score by year
PubTator Score 138.56
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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