Tclin CA6 Carbonic anhydrase 6

Protein Summary

Description

Reversible hydration of carbon dioxide. Its role in saliva is unknown. The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P23280
• E7EMQ1
• Q5FBW3
• Q5FC00
• Q96QX8
• Q9UF03

Gene Name

• CA6

Ensembl ID

• ENST00000377436
• ENSP00000366654
• ENSG00000131686
• ENST00000377442
• ENSP00000366661
• ENST00000377443
• ENSP00000366662

Symbol

• CA-VI
• GUSTIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
protein domain	0.58
hub protein	0.53
cell line	0.5
cellular component	0.47

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14

Approved Drugs (14)

Explore Approved Drugs

1 – 10 of 14

topiramate

CA6Tclin Enzyme

Ki : 7.35

imatinib

CA6Tclin Enzyme

Ki : 6.41

nilotinib

CA6Tclin Enzyme

Ki : 6.34

celecoxib

CA6Tclin Enzyme

Ki : 7.03

furosemide

CA6Tclin Enzyme

Ki : 6.61

acetazolamide

CA6Tclin Enzyme

Ki : 7.96

ethoxzolamide

CA6Tclin Enzyme

INHIBITOR Kd : 7.48

lacosamide

CA6Tclin Enzyme

Ki : 6.38

dichlorphenamide

CA6Tclin Enzyme

Ki : 7.1

dorzolamide

CA6Tclin Enzyme

Ki : 8

Active Ligands (85)

Explore Active Ligands

1 – 10 of 85

CHEMBL2333417

CA6Tclin Enzyme

Kd : 7.17

CHEMBL19

CA6Tclin Enzyme

Ki : 8

CHEMBL286738

CA6Tclin Enzyme

Ki : 6.18

CHEMBL2333416

CA6Tclin Enzyme

Kd : 6.7

CHEMBL1956579

CA6Tclin Enzyme

Ki : 7.39

CHEMBL1209039

CA6Tclin Enzyme

Ki : 6.04

CHEMBL71611

CA6Tclin Enzyme

Ki : 7.39

CHEMBL1956578

CA6Tclin Enzyme

Ki : 8.1

CHEMBL191045

CA6Tclin Enzyme

Ki : 7.23

CHEMBL1209038

CA6Tclin Enzyme

Ki : 6.12

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	carbonic anhydrase 6	VGNC:9850	457915
Macaque	carbonic anhydrase 6		709540
Mouse	carbonic anhydrase 6	MGI:1333786	12353
Rat	carbonic anhydrase 6	RGD:70516	298657
Dog	carbonic anhydrase 6	VGNC:38614	403503

Species	Name	OMA	EggNOG	Inparanoid
Chimp	carbonic anhydrase 6
Macaque	carbonic anhydrase 6
Mouse	carbonic anhydrase 6
Rat	carbonic anhydrase 6
Dog	carbonic anhydrase 6

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23280-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

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Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

IMMP1L

Tbio

Family: Enzyme

Novelty: 0.16680031

p_int: 0.999818441

p_ni: 0.000006875

p_wrong: 0.000174684

Data Source: BioPlex

FRMD1

Tdark

Novelty: 0.96833141

p_int: 0.996660743

p_ni: 1.47e-7

p_wrong: 0.00333911

Score: 0.214

Data Source: BioPlex,STRINGDB

DCAF6

Tbio

Novelty: 0.01269552

p_int: 0.99624259

p_ni: 0.00375741

Data Source: BioPlex

RHOBTB3

Tbio

Novelty: 0.09149494

p_int: 0.995268753

p_ni: 0.004730619

p_wrong: 6.28e-7

Data Source: BioPlex

PLXNA2

Tbio

Novelty: 0.01765957

p_int: 0.968383279

p_ni: 0.03161651

p_wrong: 2.11e-7

Data Source: BioPlex

DDX19B

Tbio

Family: Enzyme

Novelty: 0.0504568

p_int: 0.947034772

p_ni: 0.052965228

Score: 0.206

Data Source: BioPlex,STRINGDB

PTCD2

Tdark

Novelty: 0.23529342

p_int: 0.897044179

p_ni: 0.102953534

p_wrong: 0.000002286

Data Source: BioPlex

NPC2

Tbio

Novelty: 0.00342898

p_int: 0.884832802

p_ni: 0.115167017

p_wrong: 1.81e-7

Data Source: BioPlex

LAMB2

Tbio

Novelty: 0.07966931

p_int: 0.834284754

p_ni: 0.165715246

Data Source: BioPlex

PLXNA3

Tbio

Novelty: 0.02016528

p_int: 0.831823608

p_ni: 0.168176392

Data Source: BioPlex

Publication Statistics

PubMed Score  351.95

PubMed score by year

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PubTator Score  138.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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