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Tclin
CA6
Carbonic anhydrase 6

Protein Summary
Description
Reversible hydration of carbon dioxide. Its role in saliva is unknown. The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377436
  • ENSP00000366654
  • ENSG00000131686
  • ENST00000377442
  • ENSP00000366661
  • ENST00000377443
  • ENSP00000366662

Symbol
  • CA-VI
  • GUSTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
protein domain
0.58
hub protein
0.53
cell line
0.5
cellular component
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.95   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (62)
1 – 10 of 62
IMMP1L
Tbio
Family: Enzyme
Novelty: 0.16680031
p_int: 0.999818441
p_ni: 0.000006875
p_wrong: 0.000174684
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.996660743
p_ni: 1.47e-7
p_wrong: 0.00333911
Score: 0.214
Data Source: BioPlex,STRINGDB
DCAF6
Tbio
Novelty: 0.01269552
p_int: 0.99624259
p_ni: 0.00375741
Data Source: BioPlex
RHOBTB3
Tbio
Novelty: 0.09149494
p_int: 0.995268753
p_ni: 0.004730619
p_wrong: 6.28e-7
Data Source: BioPlex
PLXNA2
Tbio
Novelty: 0.01765957
p_int: 0.968383279
p_ni: 0.03161651
p_wrong: 2.11e-7
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.947034772
p_ni: 0.052965228
Score: 0.206
Data Source: BioPlex,STRINGDB
PTCD2
Tdark
Novelty: 0.23529342
p_int: 0.897044179
p_ni: 0.102953534
p_wrong: 0.000002286
Data Source: BioPlex
NPC2
Tbio
Novelty: 0.00342898
p_int: 0.884832802
p_ni: 0.115167017
p_wrong: 1.81e-7
Data Source: BioPlex
LAMB2
Tbio
Novelty: 0.07966931
p_int: 0.834284754
p_ni: 0.165715246
Data Source: BioPlex
PLXNA3
Tbio
Novelty: 0.02016528
p_int: 0.831823608
p_ni: 0.168176392
Data Source: BioPlex
Publication Statistics
PubMed Score  351.95

PubMed score by year
PubTator Score  138.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer