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Tbio
TUBG1
Tubulin gamma-1 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251413
  • ENSP00000251413
  • ENSG00000131462

Symbol
  • TUBG
  • TUBG
  • GCP-1
  • CDCBM4
  • TUBGCP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
molecular function
0.94
protein domain
0.92
kinase perturbation
0.84
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 515   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (226)
TUBG2
Tbio
Novelty:  0.14828466
p_int:  0.99998397
p_ni:  0.00001603
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
p_int:  0.999603713
p_ni:  0.000396287
Score:  0.993
Data Source:  BioPlex,STRINGDB
MZT1
Tdark
Novelty:  0.06713659
p_int:  0.997280091
p_ni:  0.002719909
Score:  0.999
Data Source:  BioPlex,STRINGDB
TXNDC12
Tbio
Novelty:  0.01354011
p_int:  0.993529484
p_ni:  0.006470516
Score:  0.825
Data Source:  BioPlex,STRINGDB
MZT2B
Tdark
Novelty:  0.69469786
p_int:  0.992577153
p_ni:  0.007422847
Score:  0.998
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.894705895
p_ni:  0.105294105
Score:  0.673
Data Source:  BioPlex,STRINGDB
TUBGCP6
Tbio
Novelty:  0.05801955
Score:  0.999
Data Source:  STRINGDB
TUBGCP3
Tbio
Novelty:  0.0221126
Score:  0.999
Data Source:  Reactome,STRINGDB
TUBGCP4
Tbio
Novelty:  0.04549455
Score:  0.998
Data Source:  STRINGDB
TUBGCP2
Tbio
Novelty:  0.01856674
Score:  0.997
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1
91.4
waist-hip ratio
3
5
5
81.3
sex hormone-binding globulin measurement
4
2
4
75.4
BMI-adjusted waist-hip ratio
1
3
3
73
triglyceride measurement
3
2
3
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
91.4
waist-hip ratio
5
81.3
sex hormone-binding globulin measurement
4
75.4
BMI-adjusted waist-hip ratio
3
73
triglyceride measurement
3
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma 1
VGNC:9753
454692
Mouse
MGI:101834
103733
Rat
RGD:628606
252921
Dog
tubulin, gamma 1
403695
Horse
tubulin gamma-1 chain
100052586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma 1
Mouse
Rat
Dog
tubulin, gamma 1
Horse
tubulin gamma-1 chain
Publication Statistics
PubMed Score 41.89
PubMed score by year
PubTator Score 7.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title