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Tbio
ITGA6
Integrin alpha-6

Protein Summary
Description
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that compr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264107
  • ENSP00000264107
  • ENSG00000091409
  • ENST00000409080
  • ENSP00000386896
  • ENST00000409532
  • ENSP00000386614
  • ENST00000442250
  • ENSP00000406694
  • ENST00000458358
  • ENSP00000394169

Symbol
  • CD49f
  • VLA-6
  • ITGA6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
gene perturbation
0.91
biological process
0.89
cellular component
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.19   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 1213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.19   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 1213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
5
3
0
1.3
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.3
98.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 6
VGNC:2705
459742
Macaque
integrin subunit alpha 6
697643
Mouse
MGI:96605
16403
Rat
RGD:621633
114517
Dog
integrin subunit alpha 6
VGNC:42128
100856563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 6
Macaque
integrin subunit alpha 6
Mouse
Rat
Dog
integrin subunit alpha 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23229-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (47)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Basigin interactions
Reactome
Cell junction organization
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Basigin interactions
Cell junction organization
Cell surface interactions at the vascular wall
Cell-Cell communication
Gene Ontology Terms (42)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (262)
1 – 10 of 262
ITGB4
Tbio
Novelty: 0.00386461
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
TSPAN11
Tdark
Novelty: 0.37247094
p_int: 0.999972664
p_ni: 0.000027336
Score: 0.211
Data Source: BioPlex,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
p_int: 0.999925123
p_ni: 0.000074878
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
CD151
Tbio
Novelty: 0.00295527
p_int: 0.999922571
p_ni: 0.000077377
p_wrong: 5.3e-8
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999871775
p_ni: 0.000128224
p_wrong: 1e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
RTN4
Tbio
Novelty: 0.00080371
p_int: 0.999691896
p_ni: 0.000308105
Data Source: BioPlex
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.998837263
p_ni: 0.001162735
p_wrong: 2e-9
Data Source: BioPlex
B4GALT4
Tbio
Family: Enzyme
Novelty: 0.11226614
p_int: 0.998447101
p_ni: 0.001552899
Score: 0.205
Data Source: BioPlex,STRINGDB
CD160
Tbio
Novelty: 0.01511748
p_int: 0.996322998
p_ni: 0.003677002
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.990193613
p_ni: 0.009806387
Score: 0.212
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  431.19

PubMed score by year
PubTator Score  238.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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