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Tclin
PTGS1
Prostaglandin G/H synthase 1

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tum ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223423
  • ENSP00000223423
  • ENSG00000095303
  • ENST00000362012
  • ENSP00000354612
  • ENST00000373698
  • ENSP00000362802
  • ENST00000540753
  • ENSP00000437709
  • ENST00000614910
  • ENSP00000484800

Symbol
  • COX1
  • COX1
  • COX3
  • PHS1
  • PCOX1
  • PES-1
  • PGHS1
  • PTGHS
  • PGG/HS
  • PGHS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.97
PubMedID
0.97
transcription factor perturbation
0.96
biological term
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2615.98   (req: < 5)
Gene RIFs: 200   (req: <= 3)
Antibodies: 627   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2615.98   (req: >= 5)
Gene RIFs: 200   (req: > 3)
Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 333
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42