You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PTGS1
Prostaglandin G/H synthase 1

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tum ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223423
  • ENSP00000223423
  • ENSG00000095303
  • ENST00000362012
  • ENSP00000354612
  • ENST00000373698
  • ENSP00000362802
  • ENST00000540753
  • ENSP00000437709
  • ENST00000614910
  • ENSP00000484800

Symbol
  • COX1
  • COX1
  • COX3
  • PHS1
  • PCOX1
  • PES-1
  • PGHS1
  • PTGHS
  • PGG/HS
  • PGHS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.97
PubMedID
0.97
transcription factor perturbation
0.96
biological term
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2299.24   (req: < 5)
Gene RIFs: 188   (req: <= 3)
Antibodies: 627   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2299.24   (req: >= 5)
Gene RIFs: 188   (req: > 3)
Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 322
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (42)
celecoxib
Rendered image for celecoxib
indomethacin
Rendered image for indomethacin
flufenamic acid
Rendered image for flufenamic acid
diclofenac
Rendered image for diclofenac
mefenamic acid
Rendered image for mefenamic acid
sulindac
Rendered image for sulindac
meclofenamic acid
Rendered image for meclofenamic acid
sulfasalazine
Rendered image for sulfasalazine
ibuprofen
Rendered image for ibuprofen
mesalazine
Rendered image for mesalazine
Active Ligands (322)
resveratrol
Rendered image for resveratrol
CHEMBL4476621
Rendered image for CHEMBL4476621
Clomiphene
Rendered image for Clomiphene
nimesulide
Rendered image for nimesulide
Phenothiazine
Rendered image for Phenothiazine
pterostilbene
Rendered image for pterostilbene
CHEMBL3290441
Rendered image for CHEMBL3290441
CHEMBL2323522
Rendered image for CHEMBL2323522
Caffeic acid Phenethyl Ester
Rendered image for Caffeic acid Phenethyl Ester
Protein-Protein Interactions (133)
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.981
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.973
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.97
Data Source:  STRINGDB
TBXAS1
Tchem
Family:  Enzyme
Novelty:  0.0053649
Score:  0.965
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.958
Data Source:  STRINGDB
ALOX15
Tchem
Family:  Enzyme
Novelty:  0.00184734
Score:  0.958
Data Source:  STRINGDB
ALOX12
Tchem
Family:  Enzyme
Novelty:  0.00287761
Score:  0.958
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.957
Data Source:  STRINGDB
PTGDS
Tchem
Family:  Enzyme
Novelty:  0.002111
Score:  0.951
Data Source:  STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
COX reactions
Reactome
Fatty acid metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
COX reactions
Fatty acid metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 1
VGNC:9192
464713
Macaque
prostaglandin-endoperoxide synthase 1
698213
Mouse
MGI:97797
19224
Rat
RGD:3439
24693
Dog
prostaglandin-endoperoxide synthase 1
VGNC:45151
403544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 1
Macaque
prostaglandin-endoperoxide synthase 1
Mouse
Rat
Dog
prostaglandin-endoperoxide synthase 1
Publication Statistics
PubMed Score 2299.24
PubMed score by year
PubTator Score 1015.13
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title