Tbio TCEA1 Transcription elongation factor A protein 1

Protein Summary

Description

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Uniprot Accession IDs

• P23193
• A6NF25
• A8K339
• Q15563
• Q6FG87

Gene Name

• TCEA1

Ensembl ID

• ENST00000396401
• ENSP00000395483
• ENSG00000187735
• ENST00000521604
• ENSP00000428426

Symbol

• GTF2S
• TFIIS
• SII
• TCEA
• TF2S
• GTF2S
• TFIIS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	0.97
protein domain	0.92
PubMedID	0.87
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Elongation Factor A Protein 1

Protein / Nucleic Acid Binding / Transcription Elongation Factor A Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Transcription Elongation Factor A Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0