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Tbio
TCEA1
Transcription elongation factor A protein 1

Protein Summary
Description
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396401
  • ENSP00000395483
  • ENSG00000187735
  • ENST00000521604
  • ENSP00000428426

Symbol
  • GTF2S
  • TFIIS
  • SII
  • TCEA
  • TF2S
  • GTF2S
  • TFIIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.97
protein domain
0.92
PubMedID
0.87
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (273)
BROX
Tbio
Novelty:  0.16859864
p_int:  0.999941301
p_ni:  0.000058699
Score:  0.206
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.998564112
p_ni:  0.001435863
p_wrong:  2.6e-8
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.980251979
p_ni:  0.019747083
p_wrong:  9.38e-7
Data Source:  BioPlex
PTCRA
Tbio
Novelty:  0.01307489
p_int:  0.978438939
p_ni:  0.021560972
p_wrong:  8.9e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
DUSP19
Tbio
Family:  Enzyme
Novelty:  0.13289846
p_int:  0.96871777
p_ni:  0.030328763
p_wrong:  0.000953467
Score:  0.201
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.967250872
p_ni:  0.032054375
p_wrong:  0.000694753
Data Source:  BioPlex
SLC38A7
Tdark
Family:  Transporter
Novelty:  0.24353276
p_int:  0.960831276
p_ni:  0.038406057
p_wrong:  0.000762666
Score:  0.167
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.95554729
p_ni:  0.044452501
p_wrong:  2.09e-7
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.949930035
p_ni:  0.050069421
p_wrong:  5.43e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC25A32
Tbio
Family:  Transporter
Novelty:  0.06270404
p_int:  0.945199426
p_ni:  0.054276233
p_wrong:  0.000524341
Score:  0.209
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
DNA Repair (R-HSA-73894)

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Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual incision in TC-NER
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual incision in TC-NER
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor A1
VGNC:7731
472763
Macaque
transcription elongation factor A1
693579
Mouse
MGI:1196624
21399
Rat
RGD:1309880
362479
Dog
transcription elongation factor A1
VGNC:47182
477879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor A1
Macaque
transcription elongation factor A1
Mouse
Rat
Dog
transcription elongation factor A1
Publication Statistics
PubMed Score 441.99
PubMed score by year
PubTator Score 275.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title