Protein Summary
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encode ...more
- ENST00000262722
- ENSP00000262722
- ENSG00000077942
- ENST00000327858
- ENSP00000331544
- ENST00000340923
- ENSP00000342212
- ENST00000442170
- ENSP00000393812
- FBLN
- FIBL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus | 1 | ||
protein domain | 0.99 | ||
viral protein | 0.98 | ||
PubMedID | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.62 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 300 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.62 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 300 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (110)
COLQ
Family: Enzyme
Novelty: 0.01414634
p_int: 0.997730174
p_ni: 0.002269826
Score: 0.16
Data Source: BioPlex,STRINGDB
WNT7A
Novelty: 0.00421662
p_int: 0.993948462
p_ni: 0.006051538
Score: 0.178
Data Source: BioPlex,STRINGDB
IRF9
Family: TF
Novelty: 0.00751233
p_int: 0.9936759
p_ni: 0.0063241
Score: 0.176
Data Source: BioPlex,STRINGDB
PAK5
Family: Kinase
Novelty: 0.02138632
p_int: 0.987702757
p_ni: 0.012297239
p_wrong: 4e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
PTPRK
Family: Enzyme
Novelty: 0.03149943
p_int: 0.977714873
p_ni: 0.022285127
Score: 0.151
Data Source: BioPlex,STRINGDB
EFEMP1
Novelty: 0.00574779
p_int: 0.97272535
p_ni: 0.027274649
Score: 0.935
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Molecules associated with elastic fibres | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Molecules associated with elastic fibres | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (9)
Components (7)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 4 | 4 | 4 | 93.7 | |||||
hemoglobin measurement | 3 | 3 | 3 | 91.1 | |||||
heel bone mineral density | 1 | 1 | 1 | 64 | |||||
erythrocyte count | 1 | 1 | 1 | 61 | |||||
low density lipoprotein cholesterol measurement | 2 | 1 | 2 | 59.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 4 | 93.7 | |||||
hemoglobin measurement | 3 | 91.1 | |||||
heel bone mineral density | 1 | 64 | |||||
erythrocyte count | 1 | 61 | |||||
low density lipoprotein cholesterol measurement | 2 | 59.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | fibulin 1 | 713606 | ||||||
Mouse | MGI:95487 | 14114 | ||||||
Rat | RGD:1308667 | 315191 | ||||||
Dog | fibulin 1 | VGNC:40750 | 474468 | |||||
Horse | fibulin 1 | VGNC:17930 | 100052767 | |||||
Publication Statistics
PubMed Score 141.62
PubMed score by year
PubTator Score 103.28
PubTator score by year
Related Publications
Text Mined References (99)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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