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Tbio
FBLN1
Fibulin-1

Protein Summary
Description
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262722
  • ENSP00000262722
  • ENSG00000077942
  • ENST00000327858
  • ENSP00000331544
  • ENST00000340923
  • ENSP00000342212
  • ENST00000442170
  • ENSP00000393812

Symbol
  • FBLN
  • FIBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus
1
protein domain
0.99
viral protein
0.98
PubMedID
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.57   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.57   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
1
2
86.7
erythrocyte count
1
1
1
37.2
hematocrit
1
1
1
5.6
hemoglobin measurement
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
86.7
erythrocyte count
1
37.2
hematocrit
1
5.6
hemoglobin measurement
1
4.7
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
OCLN
Tbio
Novelty: 0.00047671
p_int: 0.999967278
p_ni: 0.000032722
Data Source: BioPlex
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.999965675
p_ni: 0.000034325
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.999091139
p_ni: 0.000908861
Data Source: BioPlex
COLQ
Tbio
Family: Enzyme
Novelty: 0.01414634
p_int: 0.997730174
p_ni: 0.002269826
Score: 0.16
Data Source: BioPlex,STRINGDB
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.993948462
p_ni: 0.006051538
Score: 0.178
Data Source: BioPlex,STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.00751233
p_int: 0.9936759
p_ni: 0.0063241
Score: 0.176
Data Source: BioPlex,STRINGDB
PAK5
Tchem
Family: Kinase
Novelty: 0.02138632
p_int: 0.987702757
p_ni: 0.012297239
p_wrong: 4e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.977714873
p_ni: 0.022285127
Score: 0.151
Data Source: BioPlex,STRINGDB
EFEMP1
Tbio
Novelty: 0.00574779
p_int: 0.97272535
p_ni: 0.027274649
Score: 0.935
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.969693233
p_ni: 0.030306767
Data Source: BioPlex
Publication Statistics
PubMed Score  138.57

PubMed score by year
PubTator Score  103.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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