Protein Summary
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript ...more
- ENST00000360526
- ENSP00000353720
- ENSG00000198848
- ENST00000361503
- ENSP00000355193
- ENST00000422046
- ENSP00000390492
- ENST00000571922
- ENSP00000460045
- ENSG00000262243
- ENST00000574513
- ENSP00000461208
- ENST00000576783
- ENSP00000458586
- CES2
- SES1
- CEH
- REH
- TGH
- ACAT
- CE-1
- CES2
- HMSE
- SES1
- HMSE1
- PCE-1
- hCE-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
chemical | 0.95 | ||
drug | 0.89 | ||
gene perturbation | 0.77 | ||
small molecule perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1157.75 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 287 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1157.75 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 287 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 196
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (196)
Protein-Protein Interactions (114)
IFT20
Novelty: 0.03005088
p_int: 0.999684139
p_ni: 0.000315801
p_wrong: 6.1e-8
Data Source: BioPlex
ANKRD40
Novelty: 1.06633958
p_int: 0.995129986
p_ni: 0.004869986
p_wrong: 2.7e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
USP9Y
Family: Enzyme
p_int: 0.993154202
p_ni: 0.006786168
p_wrong: 0.00005963
Data Source: BioPlex
TTR
Novelty: 0.0001199
p_int: 0.928087171
p_ni: 0.071912805
p_wrong: 2.4e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
RNF115
Family: Enzyme
Novelty: 0.03523706
p_int: 0.88257584
p_ni: 0.117285833
p_wrong: 0.000138327
Data Source: BioPlex
FDXR
Family: Enzyme
Novelty: 0.00171588
p_int: 0.803994339
p_ni: 0.195999478
p_wrong: 0.000006183
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (16)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peptide hormone metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Metabolism | ||||
Metabolism of Angiotensinogen to Angiotensins | ||||
Metabolism of proteins | ||||
Peptide hormone metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
birth weight | 1 | 1 | 1 | 21.5 | ||||||
birth weight | 1 | 1 | 1 | 21.5 | ||||||
gut microbiome measurement | 1 | 1 | 0 | 5.5 | 14.2 | |||||
gut microbiome measurement | 1 | 1 | 0 | 5.5 | 14.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
birth weight | 1 | 21.5 | |||||
birth weight | 1 | 21.5 | |||||
gut microbiome measurement | 0 | 5.5 | 14.2 | ||||
gut microbiome measurement | 0 | 5.5 | 14.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2148202 | 104158 | ||||||
Rat | RGD:70896 | 113902 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 1157.75
PubMed score by year
PubTator Score 562.17
PubTator score by year
Related Publications
Text Mined References (105)
GeneRif Annotations (70)
Items per page:
0 of 0
PMID | Year | Title |
|---|