Protein Summary
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript ...more
- ENST00000360526
- ENSP00000353720
- ENSG00000198848
- ENST00000361503
- ENSP00000355193
- ENST00000422046
- ENSP00000390492
- ENST00000571922
- ENSP00000460045
- ENSG00000262243
- ENST00000574513
- ENSP00000461208
- ENST00000576783
- ENSP00000458586
- CES2
- SES1
- CEH
- REH
- TGH
- ACAT
- CE-1
- CES2
- HMSE
- SES1
- HMSE1
- PCE-1
- hCE-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
chemical | 0.95 | ||
drug | 0.89 | ||
gene perturbation | 0.77 | ||
small molecule perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1494.02 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 287 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1494.02 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 287 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 218
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0