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Tchem
CES1
Liver carboxylesterase 1

Protein Summary
Description
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360526
  • ENSP00000353720
  • ENSG00000198848
  • ENST00000361503
  • ENSP00000355193
  • ENST00000422046
  • ENSP00000390492
  • ENST00000571922
  • ENSP00000460045
  • ENSG00000262243
  • ENST00000574513
  • ENSP00000461208
  • ENST00000576783
  • ENSP00000458586

Symbol
  • CES2
  • SES1
  • CEH
  • REH
  • TGH
  • ACAT
  • CE-1
  • CES2
  • HMSE
  • SES1
  • HMSE1
  • PCE-1
  • hCE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
chemical
0.95
drug
0.89
gene perturbation
0.77
small molecule perturbation
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.75   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.75   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (196)
9,10-phenanthrenequinone
Rendered image for 9,10-phenanthrenequinone
Dihydrotanshinone I
Rendered image for Dihydrotanshinone I
OL135
Rendered image for OL135
CHEMBL175854
Rendered image for CHEMBL175854
CHEMBL182199
Rendered image for CHEMBL182199
CHEMBL367966
Rendered image for CHEMBL367966
CHEMBL179760
Rendered image for CHEMBL179760
CHEMBL35925
Rendered image for CHEMBL35925
Protein-Protein Interactions (114)
CES1P1
Tdark
Family:  Enzyme
p_int:  0.999999587
p_wrong:  4.13e-7
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999684139
p_ni:  0.000315801
p_wrong:  6.1e-8
Data Source:  BioPlex
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.995129986
p_ni:  0.004869986
p_wrong:  2.7e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
USP9Y
Tdark
Family:  Enzyme
p_int:  0.993154202
p_ni:  0.006786168
p_wrong:  0.00005963
Data Source:  BioPlex
TTR
Tclin
Novelty:  0.0001199
p_int:  0.928087171
p_ni:  0.071912805
p_wrong:  2.4e-8
Score:  0.27
Data Source:  BioPlex,STRINGDB
RNF115
Tbio
Family:  Enzyme
Novelty:  0.03523706
p_int:  0.88257584
p_ni:  0.117285833
p_wrong:  0.000138327
Data Source:  BioPlex
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.855122625
p_ni:  0.144877375
Data Source:  BioPlex
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.803994339
p_ni:  0.195999478
p_wrong:  0.000006183
Data Source:  BioPlex
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.979
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.958
Data Source:  STRINGDB
Pathways (16)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
21.5
birth weight
1
1
1
21.5
gut microbiome measurement
1
1
0
5.5
14.2
gut microbiome measurement
1
1
0
5.5
14.2
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
21.5
birth weight
1
21.5
gut microbiome measurement
0
5.5
14.2
gut microbiome measurement
0
5.5
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 1157.75
PubMed score by year
PubTator Score 562.17
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title