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Tchem
AMPD1
AMP deaminase 1

Protein Summary
Description
AMP deaminase plays a critical role in energy metabolism. Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369538
  • ENSP00000358551
  • ENSG00000116748
  • ENST00000520113
  • ENSP00000430075

Symbol
  • MAD
  • MADA
  • MMDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
cell line
0.69
disease
0.66
gene perturbation
0.65
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.94   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.94   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (125)
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.97
Data Source:  STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
Score:  0.969
Data Source:  STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
Score:  0.968
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.964
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.962
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.957
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.957
Data Source:  STRINGDB
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
Score:  0.944
Data Source:  STRINGDB
GMPR
Tbio
Family:  Enzyme
Novelty:  0.03505649
Score:  0.937
Data Source:  STRINGDB
IMPDH2
Tclin
Family:  Enzyme
Novelty:  0.00815361
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 15
PDE8B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE3A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (13)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
89.7
body height
1
1
1
37.6
comparative body size at age 10, self-reported
1
1
1
21.5
1
1
0
8.1
17.8
age at first sexual intercourse measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.7
body height
1
37.6
comparative body size at age 10, self-reported
1
21.5
0
8.1
17.8
age at first sexual intercourse measurement
1
2.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine monophosphate deaminase 1
VGNC:82
457144
Macaque
adenosine monophosphate deaminase 1
708801
Mouse
MGI:88015
229665
Rat
RGD:2109
25028
Dog
adenosine monophosphate deaminase 1
VGNC:37838
606901
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine monophosphate deaminase 1
Macaque
adenosine monophosphate deaminase 1
Mouse
Rat
Dog
adenosine monophosphate deaminase 1
Publication Statistics
PubMed Score 202.94
PubMed score by year
PubTator Score 183.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title