Protein Summary
AMP deaminase plays a critical role in energy metabolism. Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
- ENST00000369538
- ENSP00000358551
- ENSG00000116748
- ENST00000520113
- ENSP00000430075
- MAD
- MADA
- MMDD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.86 | ||
cell line | 0.69 | ||
disease | 0.66 | ||
gene perturbation | 0.65 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 202.94 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 202.94 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (125)
Nearest Tclin Targets (17)
Upstream (15)
Downstream (2)
1 – 5 of 15
Pathways (13)
Reactome (4)
KEGG (2)
PathwayCommons (1)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Purine salvage | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleotide salvage | ||||
Purine salvage | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (1)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 3 | 89.7 | |||||
body height | 1 | 1 | 1 | 37.6 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 21.5 | |||||
1 | 1 | 0 | 8.1 | 17.8 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 2.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 89.7 | |||||
body height | 1 | 37.6 | |||||
comparative body size at age 10, self-reported | 1 | 21.5 | |||||
0 | 8.1 | 17.8 | |||||
age at first sexual intercourse measurement | 1 | 2.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adenosine monophosphate deaminase 1 | VGNC:82 | 457144 | |||||
Macaque | adenosine monophosphate deaminase 1 | 708801 | ||||||
Mouse | MGI:88015 | 229665 | ||||||
Rat | RGD:2109 | 25028 | ||||||
Dog | adenosine monophosphate deaminase 1 | VGNC:37838 | 606901 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adenosine monophosphate deaminase 1 | |||||
Macaque | adenosine monophosphate deaminase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | adenosine monophosphate deaminase 1 | |||||
Publication Statistics
PubMed Score 202.94
PubMed score by year
PubTator Score 183.58
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (43)
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0 of 0
PMID | Year | Title |
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