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Tbio
XPA
DNA repair protein complementing XP-A cells

Protein Summary
Description
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375128
  • ENSP00000364270
  • ENSG00000136936

Symbol
  • XPAC
  • XP1
  • XPAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
disease
0.72
transcription factor perturbation
0.68
tissue sample
0.67
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.25   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.25   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Formation of Incision Complex in GG-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Formation of Incision Complex in GG-NER
Formation of TC-NER Pre-Incision Complex
Protein-Protein Interactions (222)
1 – 10 of 222
ERCC1
Tbio
Novelty: 0.00079472
p_int: 0.999986073
p_ni: 0.000012422
p_wrong: 0.000001504
Score: 0.999
Data Source: BioPlex,STRINGDB
ERCC4
Tbio
Family: Enzyme
Novelty: 0.01076913
p_int: 0.999976589
p_ni: 0.000023411
Score: 0.998
Data Source: BioPlex,STRINGDB
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.998303008
p_ni: 0.001696992
Score: 0.188
Data Source: BioPlex,STRINGDB
ZNF518A
Tdark
Novelty: 1.30119746
p_int: 0.988136228
p_ni: 0.007640973
p_wrong: 0.004222798
Score: 0.513
Data Source: BioPlex,STRINGDB
RAD23B
Tbio
Novelty: 0.00672104
Score: 0.994
Data Source: Reactome,STRINGDB
ERCC5
Tchem
Family: Enzyme
Novelty: 0.00819696
Score: 0.991
Data Source: STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.991
Data Source: STRINGDB
XPC
Tbio
Novelty: 0.00775175
Score: 0.991
Data Source: Reactome,STRINGDB
RPA2
Tbio
Novelty: 0.00879115
Score: 0.99
Data Source: STRINGDB
DDB1
Tbio
Novelty: 0.00345896
Score: 0.989
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  749.25

PubMed score by year
PubTator Score  503.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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