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Tbio
MRC1
Macrophage mannose receptor 1

Protein Summary
Description
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000569591
  • ENSP00000455897
  • ENSG00000260314

Symbol
  • CLEC13D
  • CLEC13DL
  • MRC1L1
  • MMR
  • hMR
  • CD206
  • MRC1L1
  • CLEC13D
  • CLEC13DL
  • bA541I19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.92
transcription factor perturbation
0.84
PubMedID
0.75
disease
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 960.06   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 700   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 960.06   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
5
4
4
26.9
98
liver fibrosis measurement
2
1
2
82.5
blood protein measurement
1
4
4
72.4
serum albumin measurement
2
2
2
68.5
serum gamma-glutamyl transferase measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
4
26.9
98
liver fibrosis measurement
2
82.5
blood protein measurement
4
72.4
serum albumin measurement
2
68.5
serum gamma-glutamyl transferase measurement
1
67.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97142
17533
Rat
RGD:1309353
291327
Dog
mannose receptor C-type 1
VGNC:43359
487114
Horse
mannose receptor C-type 1
VGNC:20308
100068247
Cow
mannose receptor C-type 1
VGNC:31598
787578
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mannose receptor C-type 1
Horse
mannose receptor C-type 1
Cow
mannose receptor C-type 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22897-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of soluble exogenous antigens (endosomes)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of soluble exogenous antigens (endosomes)
Immune System
Protein-Protein Interactions (187)
1 – 10 of 187
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.969
Data Source:  STRINGDB
CD207
Tbio
Novelty:  0.00313729
Score:  0.922
Data Source:  STRINGDB
FCGR1B
Tbio
Novelty:  0.01365788
Score:  0.915
Data Source:  STRINGDB
MRC2
Tbio
Novelty:  0.01100289
Score:  0.911
Data Source:  STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.9
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.878
Data Source:  STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
Score:  0.859
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.838
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.838
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.832
Data Source:  STRINGDB
Publication Statistics
PubMed Score  960.06

PubMed score by year
PubTator Score  271.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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