Tbio MRC1 Macrophage mannose receptor 1

Protein Summary

Description

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P22897
• A5PKW3
• Q5VSJ2
• Q5VSK2
• MMR

Gene Name

• MRC1

Ensembl ID

• ENST00000569591
• ENSP00000455897
• ENSG00000260314

Symbol

• CLEC13D
• CLEC13DL
• MRC1L1
• MMR
• hMR
• CD206
• MRC1L1
• CLEC13D
• CLEC13DL
• bA541I19.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
protein domain	0.92
transcription factor perturbation	0.84
PubMedID	0.75
disease	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1266.23   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 700   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1266.23   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0