Protein Summary
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000236826
- ENSP00000236826
- ENSG00000118113
- CLG1
- HNC
- CLG1
- MMP-8
- PMNL-CL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological term | 0.86 | ||
cell type or tissue | 0.76 | ||
drug | 0.72 | ||
disease | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1141.16 (req: < 5)
Gene RIFs: 151 (req: <= 3)
Antibodies: 598 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1141.16 (req: >= 5)
Gene RIFs: 151 (req: > 3)
Antibodies: 598 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 935
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (935)
Protein-Protein Interactions (166)
Nearest Tclin Targets
Pathways (21)
Reactome (7)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Collagen degradation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (4)
Components (5)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | ARUK-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood protein measurement | 6 | 10 | 10 | 98.4 | |||||
matrix metalloproteinase 1 measurement | 3 | 4 | 5 | 97.8 | |||||
matrix metalloproteinase measurement | 2 | 3 | 3 | 93.3 | |||||
interstitial collagenase measurement | 1 | 1 | 1 | 70.2 | |||||
matrix metalloproteinase 10 measurement | 1 | 1 | 1 | 57.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood protein measurement | 10 | 98.4 | |||||
matrix metalloproteinase 1 measurement | 5 | 97.8 | |||||
matrix metalloproteinase measurement | 3 | 93.3 | |||||
interstitial collagenase measurement | 1 | 70.2 | |||||
matrix metalloproteinase 10 measurement | 1 | 57.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 8 | VGNC:1104 | 740516 | |||||
Macaque | matrix metallopeptidase 8 | 703536 | ||||||
Mouse | MGI:1202395 | 17394 | ||||||
Rat | RGD:631408 | 63849 | ||||||
Dog | matrix metallopeptidase 8 | VGNC:43289 | 489429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 8 | |||||
Macaque | matrix metallopeptidase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrix metallopeptidase 8 | |||||
Publication Statistics
PubMed Score 1141.16
PubMed score by year
PubTator Score 766.68
PubTator score by year
Related Publications
Text Mined References (210)
GeneRif Annotations (151)
Items per page:
0 of 0
PMID | Year | Title |
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