Protein Classes
Protein Summary
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 953.98 (req: < 5)
Gene RIFs: 151 (req: <= 3)
Antibodies: 598 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 953.98 (req: >= 5)
Gene RIFs: 151 (req: > 3)
Antibodies: 598 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 891
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (891)
1 – 10 of 891
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 44 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 44 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 8 | VGNC:1104 | 740516 | |||||
Macaque | matrix metallopeptidase 8 | 703536 | ||||||
Mouse | MGI:1202395 | 17394 | ||||||
Rat | RGD:631408 | 63849 | ||||||
Dog | matrix metallopeptidase 8 | VGNC:43289 | 489429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 8 | |||||
Macaque | matrix metallopeptidase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrix metallopeptidase 8 | |||||
Protein Structure (25 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 25
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (21)
Reactome (7)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Collagen degradation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Gene Ontology Terms (29)
Functions (4)
Components (5)
Processes (20)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | ARUK-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (166)
1 – 10 of 166
TIMP2
Family: Enzyme
Novelty: 0.00064016
Score: 0.985
Data Source: STRINGDB
ELANE
Family: Enzyme
Novelty: 0.00026112
Score: 0.967
Data Source: STRINGDB
MMP9
Family: Enzyme
Novelty: 0.00008645
Score: 0.964
Data Source: STRINGDB
DEFA4
Novelty: 0.04566082
Score: 0.959
Data Source: STRINGDB
TCN1
Novelty: 0.00305315
Score: 0.955
Data Source: STRINGDB
PLG
Family: Enzyme
Novelty: 0.00004806
Score: 0.954
Data Source: STRINGDB
ARG1
Family: Enzyme
Novelty: 0.00063728
Score: 0.95
Data Source: STRINGDB
LTF
Novelty: 0.00114254
Score: 0.949
Data Source: STRINGDB
LCN2
Family: Enzyme
Novelty: 0.00034678
Score: 0.948
Data Source: STRINGDB
CXCL1
Novelty: 0.00059123
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score 953.98
PubMed score by year
PubTator Score 766.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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