Tchem MMP8 Neutrophil collagenase

Protein Summary

Description

Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P22894
• Q45F99

Gene Name

• MMP8

Ensembl ID

• ENST00000236826
• ENSP00000236826
• ENSG00000118113

Symbol

• CLG1
• HNC
• CLG1
• MMP-8
• PMNL-CL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological term	0.86
cell type or tissue	0.76
drug	0.72
disease	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 994.84   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 598   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 994.84   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 935

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Active Ligands (935)

Explore Active Ligands

1 – 10 of 935

Galardin

MMP8Tchem Enzyme

pKi : 9.74

CGS-27023

MMP8Tchem Enzyme

pIC50 : 8.7

CHEMBL187092

MMP8Tchem Enzyme

pIC50 : 9

SL422

MMP8Tchem Enzyme

pKi : 9.3

CHEMBL79433

MMP8Tchem Enzyme

pIC50 : 9

CHEMBL471537

MMP8Tchem Enzyme

pIC50 : 9.54

CHEMBL91636

MMP8Tchem Enzyme

pKi : 8.96

BMS-561392

MMP8Tchem Enzyme

pIC50 : 6.52

marimastat

MMP8Tchem Enzyme

pIC50 : 9.33

CHEMBL440498

MMP8Tchem Enzyme

pIC50 : 10.01

Protein-Protein Interactions (166)

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1 – 10 of 166

• See Interactions on String-DB

TIMP2

Tbio

Family:  Enzyme

Novelty:  0.00064016

Score:  0.985

Data Source:  STRINGDB

ELANE

Tclin

Family:  Enzyme

Novelty:  0.00026112

Score:  0.967

Data Source:  STRINGDB

MMP9

Tchem

Family:  Enzyme

Novelty:  0.00008645

Score:  0.964

Data Source:  STRINGDB

DEFA4

Tbio

Novelty:  0.04566082

Score:  0.959

Data Source:  STRINGDB

TCN1

Tbio

Novelty:  0.00305315

Score:  0.955

Data Source:  STRINGDB

PLG

Tclin

Family:  Enzyme

Novelty:  0.00004806

Score:  0.954

Data Source:  STRINGDB

ARG1

Tchem

Family:  Enzyme

Novelty:  0.00063728

Score:  0.95

Data Source:  STRINGDB

LTF

Tbio

Novelty:  0.00114254

Score:  0.949

Data Source:  STRINGDB

LCN2

Tbio

Family:  Enzyme

Novelty:  0.00034678

Score:  0.948

Data Source:  STRINGDB

CXCL1

Tbio

Novelty:  0.00059123

Score:  0.941

Data Source:  STRINGDB

Pathways (21)

Reactome (7)

PathwayCommons (1)

WikiPathways (13)

Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Collagen degradation	40 targets	R-HSA-1442490
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (29)

Functions (4)

Components (5)

Processes (20)

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GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
endopeptidase activity	Inferred from Mutant Phenotype (IMP)	ARUK-UCL
metalloendopeptidase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Traceable Author Statement (TAS)	UniProtKB

GWAS Traits (6)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
matrix metalloproteinase 1 measurement	EFO_0010588	2	4	4		98.8
blood protein measurement	EFO_0007937	1	1	1		86.8
matrix metalloproteinase measurement	EFO_0004744	1	2	2		84.6
matrix metalloproteinase 10 measurement	EFO_0010589	1	1	1		49.5
epilepsy	EFO_0000474	1	1	0	1.1	21.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
matrix metalloproteinase 1 measurement	EFO_0010588	4		98.8
blood protein measurement	EFO_0007937	1		86.8
matrix metalloproteinase measurement	EFO_0004744	2		84.6
matrix metalloproteinase 10 measurement	EFO_0010589	1		49.5
epilepsy	EFO_0000474	0	1.1	21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
epilepsy
matrix metalloproteinase 1 measurement
matrix metalloproteinase 10 measurement
matrix metalloproteinase measurement
urinary metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
immune system phenotype
neoplasm

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 8	VGNC:1104	740516
Macaque	matrix metallopeptidase 8		703536
Mouse	matrix metallopeptidase 8	MGI:1202395	17394
Rat	matrix metallopeptidase 8	RGD:631408	63849
Dog	matrix metallopeptidase 8	VGNC:43289	489429

Species	Name	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 8
Macaque	matrix metallopeptidase 8
Mouse	matrix metallopeptidase 8
Rat	matrix metallopeptidase 8
Dog	matrix metallopeptidase 8

Publication Statistics

PubMed Score 994.84

PubMed score by year

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PubTator Score 766.68

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