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Tchem
MMP8
Neutrophil collagenase

Protein Summary
Description
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236826
  • ENSP00000236826
  • ENSG00000118113

Symbol
  • CLG1
  • HNC
  • CLG1
  • MMP-8
  • PMNL-CL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.86
cell type or tissue
0.76
drug
0.72
disease
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.98   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.98   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 891
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
44
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 8
VGNC:1104
740516
Macaque
matrix metallopeptidase 8
703536
Mouse
MGI:1202395
17394
Rat
RGD:631408
63849
Dog
matrix metallopeptidase 8
VGNC:43289
489429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 8
Macaque
matrix metallopeptidase 8
Mouse
Rat
Dog
matrix metallopeptidase 8
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22894-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Immune System
Protein-Protein Interactions (166)
1 – 10 of 166
TIMP2
Tbio
Family: Enzyme
Novelty: 0.00064016
Score: 0.985
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.967
Data Source: STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
Score: 0.964
Data Source: STRINGDB
DEFA4
Tbio
Novelty: 0.04566082
Score: 0.959
Data Source: STRINGDB
TCN1
Tbio
Novelty: 0.00305315
Score: 0.955
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.954
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.95
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.949
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.948
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  953.98

PubMed score by year
PubTator Score  766.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer