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Tbio
PROZ
Vitamin K-dependent protein Z

Protein Summary
Description
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342783
  • ENSP00000344458
  • ENSG00000126231
  • ENST00000375547
  • ENSP00000364697

Symbol
  • PZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.69
biological term
0.68
disease perturbation
0.62
gene perturbation
0.59


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.18   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.18   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein Z, vitamin K dependent plasma glycoprotein
VGNC:9812
467342
Macaque
protein Z, vitamin K dependent plasma glycoprotein
696982
Mouse
MGI:1860488
66901
Rat
RGD:1308666
306608
Horse
protein Z, vitamin K dependent plasma glycoprotein
VGNC:21879
100067119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein Z, vitamin K dependent plasma glycoprotein
Macaque
protein Z, vitamin K dependent plasma glycoprotein
Mouse
Rat
Horse
protein Z, vitamin K dependent plasma glycoprotein
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Reactome
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (94)
1 – 10 of 94
FOXG1
Tbio
Family: TF
Novelty: 0.00154897
p_int: 0.999986424
p_ni: 0.000013566
p_wrong: 1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
INTS6
Tbio
Novelty: 0.02680242
p_int: 0.999984491
p_ni: 0.000015509
Data Source: BioPlex
IP6K3
Tbio
Family: Kinase
Novelty: 0.13072912
p_int: 0.999945186
p_ni: 0.000054784
p_wrong: 3e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
ATP23
Tbio
Family: Enzyme
Novelty: 0.09823059
p_int: 0.999918068
p_ni: 0.000040681
p_wrong: 0.000041251
Data Source: BioPlex
FOXF2
Tbio
Family: TF
Novelty: 0.02032168
p_int: 0.999629476
p_ni: 0.000082536
p_wrong: 0.000287988
Data Source: BioPlex
OR52W1
Tdark
Family: oGPCR
Novelty: 7.15909091
p_int: 0.998054434
p_ni: 0.001945068
p_wrong: 4.99e-7
Score: 0.351
Data Source: BioPlex,STRINGDB
SIPA1L2
Tbio
Novelty: 0.2002618
p_int: 0.996500169
p_ni: 0.003463809
p_wrong: 0.000036021
Data Source: BioPlex
SDF2L1
Tbio
Novelty: 0.12184663
p_int: 0.995495628
p_ni: 0.004504372
Data Source: BioPlex
SIK2
Tchem
Family: Kinase
Novelty: 0.01957886
p_int: 0.993832175
p_ni: 0.005384717
p_wrong: 0.000783107
Score: 0.183
Data Source: BioPlex,STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
p_int: 0.992287246
p_ni: 0.007711016
p_wrong: 0.000001738
Data Source: BioPlex
Publication Statistics
PubMed Score  18.18

PubMed score by year
PubTator Score  9.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer