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Tclin
LHCGR
Lutropin-choriogonadotropic hormone receptor

Protein Summary
Description
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294954
  • ENSP00000294954
  • ENSG00000138039

Symbol
  • LCGR
  • LGR2
  • LHRHR
  • HHG
  • LHR
  • LCGR
  • LGR2
  • ULG5
  • LHRHR
  • LSH-R
  • LH/CGR
  • LH/CG-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.84
biological process
0.83
phenotype
0.75
cellular component
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.08   (req: < 5)
Gene RIFs: 162   (req: <= 3)
Antibodies: 559   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.08   (req: >= 5)
Gene RIFs: 162   (req: > 3)
Antibodies: 559   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (207)
LHB
Tbio
Novelty:  0.00196754
Score:  0.975
Data Source:  Reactome,STRINGDB
INSL3
Tbio
Novelty:  0.00374656
Score:  0.962
Data Source:  STRINGDB
CGA
Tbio
Novelty:  0.00394017
Score:  0.96
Data Source:  Reactome,STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.959
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.959
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.959
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.959
Data Source:  STRINGDB
FSHB
Tbio
Novelty:  0.00510815
Score:  0.954
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.953
Data Source:  STRINGDB
AVPR2
Tclin
Family:  GPCR
Novelty:  0.0009139
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
7
9
87.9
waist-hip ratio
3
7
9
87.4
body mass index
3
3
3
81.8
high density lipoprotein cholesterol measurement
2
1
2
76
2
1
0
1.4
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
87.9
waist-hip ratio
9
87.4
body mass index
3
81.8
high density lipoprotein cholesterol measurement
2
76
0
1.4
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
luteinizing hormone/choriogonadotropin receptor
100615277
Macaque
luteinizing hormone/choriogonadotropin receptor
715999
Mouse
MGI:96783
16867
Rat
RGD:3007
25477
Dog
luteinizing hormone/choriogonadotropin receptor
VGNC:54524
481365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
luteinizing hormone/choriogonadotropin receptor
Macaque
luteinizing hormone/choriogonadotropin receptor
Mouse
Rat
Dog
luteinizing hormone/choriogonadotropin receptor
Publication Statistics
PubMed Score 590.08
PubMed score by year
PubTator Score 937.76
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title