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Tbio
GNLY
Granulysin

Protein Summary
Description
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263863
  • ENSP00000263863
  • ENSG00000115523
  • ENST00000409696
  • ENSP00000387116

Symbol
  • LAG2
  • NKG5
  • TLA519
  • LAG2
  • NKG5
  • LAG-2
  • D2S69E
  • TLA519
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.64
PubMedID
0.57
tissue sample
0.57
cellular component
0.53
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.32   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.32   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PRF1
Tchem
Novelty:  0.0002835
Score:  0.953
Data Source:  STRINGDB
GZMB
Tchem
Family:  Enzyme
Novelty:  0.00052869
Score:  0.938
Data Source:  STRINGDB
GZMA
Tbio
Family:  Enzyme
Novelty:  0.00322362
Score:  0.923
Data Source:  STRINGDB
GZMH
Tbio
Family:  Enzyme
Novelty:  0.01480634
Score:  0.885
Data Source:  STRINGDB
NKG7
Tdark
Novelty:  0.0599879
Score:  0.883
Data Source:  STRINGDB
SRRT
Tbio
Novelty:  0.00429818
Score:  0.83
Data Source:  STRINGDB
LAG3
Tbio
Novelty:  0.00187736
Score:  0.76
Data Source:  STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
Score:  0.751
Data Source:  STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.691
Data Source:  STRINGDB
IL15
Tbio
Novelty:  0.00049351
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
56
reticulocyte count
1
1
1
44.2
reticulocyte measurement
1
1
1
42.3
serum gamma-glutamyl transferase measurement
1
1
1
33.1
disease progression measurement
1
1
0
20.9
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
56
reticulocyte count
1
44.2
reticulocyte measurement
1
42.3
serum gamma-glutamyl transferase measurement
1
33.1
disease progression measurement
0
20.9
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
granulysin
VGNC:267
459370
Horse
granulysin
VGNC:49458
100034133
Cow
uncharacterized LOC616323
616323
Pig
granulysin
396869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
granulysin
Horse
granulysin
Cow
uncharacterized LOC616323
Pig
granulysin
Publication Statistics
PubMed Score 553.32
PubMed score by year
PubTator Score 222.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title