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Tchem
NR4A1
Nuclear receptor subfamily 4 group A member 1

Protein Summary
Description
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243050
  • ENSP00000243050
  • ENSG00000123358
  • ENST00000360284
  • ENSP00000353427
  • ENST00000394824
  • ENSP00000378301
  • ENST00000394825
  • ENSP00000378302
  • ENST00000548232
  • ENSP00000449587
  • ENST00000550082
  • ENSP00000449539

Symbol
  • GFRP1
  • HMR
  • NAK1
  • HMR
  • N10
  • TR3
  • NP10
  • GFRP1
  • NAK-1
  • NGFIB
  • NUR77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.92
small molecule perturbation
0.9
biological term
0.87
kinase
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0