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Tchem
NR4A1
Nuclear receptor subfamily 4 group A member 1

Protein Summary
Description
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243050
  • ENSP00000243050
  • ENSG00000123358
  • ENST00000360284
  • ENSP00000353427
  • ENST00000394824
  • ENSP00000378301
  • ENST00000394825
  • ENSP00000378302
  • ENST00000548232
  • ENSP00000449587
  • ENST00000550082
  • ENSP00000449539

Symbol
  • GFRP1
  • HMR
  • NAK1
  • HMR
  • N10
  • TR3
  • NP10
  • GFRP1
  • NAK-1
  • NGFIB
  • NUR77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.92
small molecule perturbation
0.9
biological term
0.87
kinase
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 836.52   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 836.52   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (172)
MIDN
Tbio
Novelty:  0.0730514
p_int:  0.999993743
p_ni:  0.000006254
p_wrong:  3e-9
Score:  0.38
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.997953552
p_ni:  0.002046448
Score:  0.167
Data Source:  BioPlex,STRINGDB
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.995380876
p_ni:  0.004619107
p_wrong:  1.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
p_int:  0.763961156
p_ni:  0.235964274
p_wrong:  0.00007457
Score:  0.243
Data Source:  BioPlex,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.984
Data Source:  Reactome,STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.968
Data Source:  STRINGDB
BCL2
Tclin
Novelty:  0.00608635
Score:  0.958
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.955
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.951
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.95
Data Source:  STRINGDB
Pathways (26)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
Disease
Diseases of signal transduction
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
90.3
mean corpuscular hemoglobin concentration
1
1
1
82
wellbeing measurement
3
2
3
53.3
granulocyte count
1
1
1
49.5
sum of neutrophil and eosinophil counts
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
90.3
mean corpuscular hemoglobin concentration
1
82
wellbeing measurement
3
53.3
granulocyte count
1
49.5
sum of neutrophil and eosinophil counts
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 1
VGNC:5507
451913
Macaque
nuclear receptor subfamily 4 group A member 1
696797
Mouse
MGI:1352454
15370
Rat
RGD:620029
79240
Dog
nuclear receptor subfamily 4 group A member 1
VGNC:43954
403897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 4 group A member 1
Macaque
nuclear receptor subfamily 4 group A member 1
Mouse
Rat
Dog
nuclear receptor subfamily 4 group A member 1
Publication Statistics
PubMed Score 836.52
PubMed score by year
PubTator Score 2495.32
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title