Tchem NR4A1 Nuclear receptor subfamily 4 group A member 1

Protein Summary

Description

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P22736
• B4DML7
• Q15627
• Q53Y00
• Q6IBU8

Gene Name

• NR4A1

Ensembl ID

• ENST00000243050
• ENSP00000243050
• ENSG00000123358
• ENST00000360284
• ENSP00000353427
• ENST00000394824
• ENSP00000378301
• ENST00000394825
• ENSP00000378302
• ENST00000548232
• ENSP00000449587
• ENST00000550082
• ENSP00000449539

Symbol

• GFRP1
• HMR
• NAK1
• HMR
• N10
• TR3
• NP10
• GFRP1
• NAK-1
• NGFIB
• NUR77

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.92
small molecule perturbation	0.9
biological term	0.87
kinase	0.87

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Receptor Subfamily 4 Group A Member 1

Protein / Receptor / Nuclear Receptor Subfamily 4 Group A Member 1

Protein / ... / C4 Zinc Finger Nuclear Receptor / Nuclear Receptor Subfamily 4 Group A Member 1

DTO Classes

Protein / Nuclear Receptor / Nerve Growth Factor Ib-like Receptors / Nuclear Receptor Subfamily 4 Group A Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: < 5)

Gene RIFs: 240   (req: <= 3)

Antibodies: 656   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: >= 5)

Gene RIFs: 240   (req: > 3)

Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0