Tchem TGM1 Protein-glutamine gamma-glutamyltransferase K

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase K

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase K

Protein Summary

Description

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22735
• B4DWR7
• Q197M4

Gene Name

• TGM1

Ensembl ID

• ENST00000206765
• ENSP00000206765
• ENSG00000092295
• ENST00000544573
• ENSP00000439446
• ENST00000642845
• ENSP00000493587
• ENSG00000285348
• ENST00000646057
• ENSP00000496483

Symbol

• KTG
• LI
• KTG
• LI1
• TGK
• ICR2
• ARCI1
• TGASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
protein domain	0.92
interacting protein	0.8
PubMedID	0.62
transcription factor	0.6

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.95   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.95   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

CHEMBL2086889

TGM1Tchem Enzyme

IC50 : 7.75

CHEMBL2086891

TGM1Tchem Enzyme

IC50 : 6.02

CHEMBL2152090

TGM1Tchem Enzyme

IC50 : 6.04

CHEMBL193220

TGM1Tchem Enzyme

IC50 : 6.6

GWAS Traits (2)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
telomere length	EFO_0004505	ENSG00000092295	1	1	1		88
telomere length	EFO_0004505	ENSG00000285348	1	1	1		88

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
telomere length	EFO_0004505	1		88
telomere length	EFO_0004505	1		88

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transglutaminase 1	VGNC:3303	452814
Macaque	transglutaminase 1		715854
Mouse	transglutaminase 1, K polypeptide	MGI:98730	21816
Rat	transglutaminase 1	RGD:61838	60335
Dog	transglutaminase 1	VGNC:47315	403630

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transglutaminase 1
Macaque	transglutaminase 1
Mouse	transglutaminase 1, K polypeptide
Rat	transglutaminase 1
Dog	transglutaminase 1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Developmental Biology (R-HSA-1266738)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (14)

Functions (2)

Components (5)

Processes (7)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein-glutamine gamma-glutamyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (132)

Explore Interacting Targets

1 – 10 of 132

• See Interactions on String-DB

TEFM

Tbio

Novelty: 0.10836617

p_int: 0.997772971

p_ni: 0.002227029

Data Source: BioPlex

TBC1D22B

Tbio

Novelty: 0.49852962

p_int: 0.995602528

p_ni: 0.004397472

Data Source: BioPlex

ZIC1

Tbio

Family: TF

Novelty: 0.00491601

p_int: 0.991456447

p_ni: 0.008543553

Data Source: BioPlex

KLHL11

Tbio

Novelty: 0.1537041

p_int: 0.990956173

p_ni: 0.009043827

Data Source: BioPlex

HES4

Tbio

Family: TF

Novelty: 0.05290912

p_int: 0.974020018

p_ni: 0.025979982

Data Source: BioPlex

FTH1

Tbio

Novelty: 0.000863

p_int: 0.973446954

p_ni: 0.026553046

Score: 0.168

Data Source: BioPlex,STRINGDB

NPPA

Tchem

Novelty: 0.00046693

p_int: 0.967286237

p_ni: 0.032713762

p_wrong: 1e-9

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.13274675

p_int: 0.958774058

p_ni: 0.041225942

Data Source: BioPlex

CCDC51

Tdark

Novelty: 1.19203634

p_int: 0.948181774

p_ni: 0.051818226

Data Source: BioPlex

GMCL1

Tbio

Novelty: 0.1543762

p_int: 0.948030294

p_ni: 0.051969706

Data Source: BioPlex

Publication Statistics

PubMed Score  1026.95

PubMed score by year

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PubTator Score  572.01

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Disease mutation
Ichthyosis
Keratinization
Lipoprotein
Membrane

GWAS Trait Find Similar Targets

telomere length

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging