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Tchem
TGM1
Protein-glutamine gamma-glutamyltransferase K

Protein Summary
Description
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206765
  • ENSP00000206765
  • ENSG00000092295
  • ENST00000544573
  • ENSP00000439446
  • ENST00000642845
  • ENSP00000493587
  • ENSG00000285348
  • ENST00000646057
  • ENSP00000496483

Symbol
  • KTG
  • LI
  • KTG
  • LI1
  • TGK
  • ICR2
  • ARCI1
  • TGASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
protein domain
0.92
interacting protein
0.8
PubMedID
0.62
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.95   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.95   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
88
telomere length
1
1
1
88
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
88
telomere length
1
88
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 1
VGNC:3303
452814
Macaque
transglutaminase 1
715854
Mouse
MGI:98730
21816
Rat
RGD:61838
60335
Dog
transglutaminase 1
VGNC:47315
403630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 1
Macaque
transglutaminase 1
Mouse
Rat
Dog
transglutaminase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (132)
1 – 10 of 132
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.997772971
p_ni: 0.002227029
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.995602528
p_ni: 0.004397472
Data Source: BioPlex
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.991456447
p_ni: 0.008543553
Data Source: BioPlex
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.990956173
p_ni: 0.009043827
Data Source: BioPlex
HES4
Tbio
Family: TF
Novelty: 0.05290912
p_int: 0.974020018
p_ni: 0.025979982
Data Source: BioPlex
FTH1
Tbio
Novelty: 0.000863
p_int: 0.973446954
p_ni: 0.026553046
Score: 0.168
Data Source: BioPlex,STRINGDB
NPPA
Tchem
Novelty: 0.00046693
p_int: 0.967286237
p_ni: 0.032713762
p_wrong: 1e-9
Data Source: BioPlex
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.958774058
p_ni: 0.041225942
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.948181774
p_ni: 0.051818226
Data Source: BioPlex
GMCL1
Tbio
Novelty: 0.1543762
p_int: 0.948030294
p_ni: 0.051969706
Data Source: BioPlex
Publication Statistics
PubMed Score  1026.95

PubMed score by year
PubTator Score  572.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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