TGM1
Protein-glutamine gamma-glutamyltransferase K
Protein Summary
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
- ENST00000206765
- ENSP00000206765
- ENSG00000092295
- ENST00000544573
- ENSP00000439446
- ENST00000642845
- ENSP00000493587
- ENSG00000285348
- ENST00000646057
- ENSP00000496483
- KTG
- LI
- KTG
- LI1
- TGK
- ICR2
- ARCI1
- TGASE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
protein domain | 0.92 | ||
interacting protein | 0.8 | ||
PubMedID | 0.62 | ||
transcription factor | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1074.67 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1074.67 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (132)
FTH1
Novelty: 0.000863
p_int: 0.973446954
p_ni: 0.026553046
Score: 0.168
Data Source: BioPlex,STRINGDB
NPPA
Novelty: 0.00046693
p_int: 0.967286237
p_ni: 0.032713762
p_wrong: 1e-9
Data Source: BioPlex
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.958774058
p_ni: 0.041225942
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
telomere length | 1 | 1 | 1 | 82.9 | ||||||
telomere length | 1 | 1 | 1 | 82.9 | ||||||
platelet count | 2 | 2 | 2 | 75 | ||||||
platelet count | 2 | 2 | 2 | 75 | ||||||
mean corpuscular volume | 2 | 2 | 2 | 62 | ||||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
telomere length | 1 | 82.9 | |||||
telomere length | 1 | 82.9 | |||||
platelet count | 2 | 75 | |||||
platelet count | 2 | 75 | |||||
mean corpuscular volume | 2 | 62 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transglutaminase 1 | VGNC:3303 | 452814 | |||||
Macaque | transglutaminase 1 | 715854 | ||||||
Mouse | MGI:98730 | 21816 | ||||||
Rat | RGD:61838 | 60335 | ||||||
Dog | transglutaminase 1 | VGNC:47315 | 403630 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transglutaminase 1 | |||||
Macaque | transglutaminase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transglutaminase 1 | |||||
Publication Statistics
PubMed Score 1074.67
PubMed score by year
PubTator Score 572.01
PubTator score by year
Related Publications
Text Mined References (117)
GeneRif Annotations (71)
Items per page:
0 of 0
PMID | Year | Title |
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