Tchem TGM1 Protein-glutamine gamma-glutamyltransferase K

Protein Summary

Description

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22735
• B4DWR7
• Q197M4

Gene Name

• TGM1

Ensembl ID

• ENST00000206765
• ENSP00000206765
• ENSG00000092295
• ENST00000544573
• ENSP00000439446
• ENST00000642845
• ENSP00000493587
• ENSG00000285348
• ENST00000646057
• ENSP00000496483

Symbol

• KTG
• LI
• KTG
• LI1
• TGK
• ICR2
• ARCI1
• TGASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
protein domain	0.92
interacting protein	0.8
PubMedID	0.62
transcription factor	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase K

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase K

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1403.76   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1403.76   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0