TGM1
Protein-glutamine gamma-glutamyltransferase K
Protein Summary
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
- ENST00000206765
- ENSP00000206765
- ENSG00000092295
- ENST00000544573
- ENSP00000439446
- ENST00000642845
- ENSP00000493587
- ENSG00000285348
- ENST00000646057
- ENSP00000496483
- KTG
- LI
- KTG
- LI1
- TGK
- ICR2
- ARCI1
- TGASE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
protein domain | 0.92 | ||
interacting protein | 0.8 | ||
PubMedID | 0.62 | ||
transcription factor | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1403.76 (req: < 5)
Gene RIFs: 83 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1403.76 (req: >= 5)
Gene RIFs: 83 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0