UQCRC2
Cytochrome b-c1 complex subunit 2, mitochondrial
Protein Summary
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
- ENST00000268379
- ENSP00000268379
- ENSG00000140740
- ENST00000639558
- ENSP00000491124
- ENSG00000284493
- QCR2
- UQCR2
- MC3DN5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.95 | ||
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.52 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.52 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0