UQCRC2
Cytochrome b-c1 complex subunit 2, mitochondrial
Protein Summary
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
- ENST00000268379
- ENSP00000268379
- ENSG00000140740
- ENST00000639558
- ENSP00000491124
- ENSG00000284493
- QCR2
- UQCR2
- MC3DN5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.95 | ||
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.09 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.09 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (247)
UQCRQ
Novelty: 0.04392627
p_int: 0.981556423
p_ni: 0.018443577
Score: 0.999
Data Source: BioPlex,STRINGDB
UQCRB
Novelty: 0.02933046
p_int: 0.941149922
p_ni: 0.058850078
Score: 0.999
Data Source: BioPlex,STRINGDB
COX4I1
Family: Enzyme
Novelty: 0.00208873
p_int: 0.890823226
p_ni: 0.109176774
Score: 0.973
Data Source: BioPlex,STRINGDB
UQCRH
Novelty: 0.04494433
p_int: 0.829847215
p_ni: 0.170152785
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
Reactome (4)
KEGG (8)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquinol-cytochrome c reductase core protein 2 | VGNC:9404 | 468094 | |||||
Macaque | ubiquinol-cytochrome c reductase core protein II | 697967 | ||||||
Mouse | MGI:1914253 | 67003 | ||||||
Rat | RGD:1359150 | 293448 | ||||||
Dog | ubiquinol-cytochrome c reductase core protein 2 | VGNC:48164 | 479815 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquinol-cytochrome c reductase core protein 2 | |||||
Macaque | ubiquinol-cytochrome c reductase core protein II | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquinol-cytochrome c reductase core protein 2 | |||||
Publication Statistics
PubMed Score 58.09
PubMed score by year
PubTator Score 10.23
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (4)
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