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Tbio
CBL
E3 ubiquitin-protein ligase CBL

Protein Summary
Description
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264033
  • ENSP00000264033
  • ENSG00000110395

Symbol
  • CBL2
  • RNF55
  • CBL2
  • NSLL
  • C-CBL
  • RNF55
  • FRA11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological term
0.98
interacting protein
0.97
kinase
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.69   (req: < 5)
Gene RIFs: 208   (req: <= 3)
Antibodies: 1056   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.69   (req: >= 5)
Gene RIFs: 208   (req: > 3)
Antibodies: 1056   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (454)
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.422
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999995928
p_ni:  0.000004072
Score:  0.966
Data Source:  BioPlex,STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999859188
p_ni:  0.000123706
p_wrong:  0.000017106
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.999656823
p_ni:  0.000343177
Score:  0.298
Data Source:  BioPlex,STRINGDB
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.99594151
p_ni:  0.00405849
p_wrong:  1e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.872426547
p_ni:  0.126835139
p_wrong:  0.000738314
Data Source:  BioPlex
SPRY2
Tbio
Novelty:  0.00884945
Score:  0.998
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.998
Data Source:  Reactome,STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.998
Data Source:  STRINGDB
Pathways (108)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by EGFRvIII
Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
6
7
6.3
99.2
platelet crit
2
5
6
98.2
urate measurement
4
3
4
86.3
sex hormone-binding globulin measurement
6
3
6
78.6
reticulocyte count
6
1
6
76.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
6.3
99.2
platelet crit
6
98.2
urate measurement
4
86.3
sex hormone-binding globulin measurement
6
78.6
reticulocyte count
6
76.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene
VGNC:10188
451690
Macaque
Cbl proto-oncogene
704311
Mouse
MGI:88279
12402
Rat
RGD:1561386
500985
Dog
Cbl proto-oncogene
VGNC:38758
489369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene
Macaque
Cbl proto-oncogene
Mouse
Rat
Dog
Cbl proto-oncogene
Publication Statistics
PubMed Score 890.69
PubMed score by year
PubTator Score 728.17
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title