You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CYP7A1
Cholesterol 7-alpha-monooxygenase

Protein Summary
Description
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301645
  • ENSP00000301645
  • ENSG00000167910

Symbol
  • CYP7
  • CP7A
  • CYP7
  • CYPVII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.75
chemical
0.73
disease
0.73
biological term
0.67
pathway
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.68   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.68   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (192)
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.996
Data Source:  STRINGDB
CYP27A1
Tchem
Family:  Enzyme
Novelty:  0.00071796
Score:  0.987
Data Source:  STRINGDB
HSD3B7
Tbio
Family:  Enzyme
Novelty:  0.04791842
Score:  0.977
Data Source:  STRINGDB
NR0B2
Tchem
Family:  NR
Novelty:  0.0009861
Score:  0.973
Data Source:  STRINGDB
CH25H
Tbio
Family:  Enzyme
Novelty:  0.01620877
Score:  0.966
Data Source:  STRINGDB
CYP46A1
Tchem
Family:  Enzyme
Novelty:  0.01549935
Score:  0.964
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.959
Data Source:  STRINGDB
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.958
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.949
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
CYP17A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (35)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
26
12
38
98.3
total cholesterol measurement
18
12
29
97.7
triglyceride measurement
19
8
19
96.2
apolipoprotein B measurement
3
3
3
91.2
sex hormone-binding globulin measurement
4
2
4
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
38
98.3
total cholesterol measurement
29
97.7
triglyceride measurement
19
96.2
apolipoprotein B measurement
3
91.2
sex hormone-binding globulin measurement
4
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 7 subfamily A member 1
VGNC:6563
464191
Macaque
cytochrome P450, family 7, subfamily A, polypeptide 1
698127
Mouse
MGI:106091
13122
Rat
RGD:2482
25428
Dog
cytochrome P450 family 7 subfamily A member 1
VGNC:50378
486962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 7 subfamily A member 1
Macaque
cytochrome P450, family 7, subfamily A, polypeptide 1
Mouse
Rat
Dog
cytochrome P450 family 7 subfamily A member 1
Publication Statistics
PubMed Score 777.68
PubMed score by year
PubTator Score 415.95
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title