Tbio RFX1 MHC class II regulatory factor RFX1

Protein Summary

Description

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P22670

Gene Name

• RFX1

Ensembl ID

• ENST00000254325
• ENSP00000254325
• ENSG00000132005

Symbol

• EFC
• RFX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
disease perturbation	0.79
hub protein	0.79
histone modification site profile	0.76
interacting protein	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mhc Class Ii Regulatory Factor Rfx1

Protein / ... / Winged Helix/forkhead Transcription Factor / Mhc Class Ii Regulatory Factor Rfx1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Mhc Class Ii Regulatory Factor Rfx1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 613.02   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 613.02   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0