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Tbio
HNRNPA2B1
Heterogeneous nuclear ribonucleoproteins A2/B1

Protein Summary
Description
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354667
  • ENSP00000346694
  • ENSG00000122566
  • ENST00000356674
  • ENSP00000349101
  • ENST00000360787
  • ENSP00000354021
  • ENST00000608362
  • ENSP00000497298

Symbol
  • HNRPA2B1
  • RNPA2
  • HNRPA2
  • HNRPB1
  • SNRPB1
  • HNRNPA2
  • HNRNPB1
  • IBMPFD2
  • HNRPA2B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.11   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.11   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein A2/B1
VGNC:14021
463299
Macaque
heterogeneous nuclear ribonucleoprotein A2/B1
701821
Mouse
MGI:104819
53379
Rat
RGD:1310403
362361
Dog
heterogeneous nuclear ribonucleoprotein A2/B1
VGNC:41727
475260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein A2/B1
Macaque
heterogeneous nuclear ribonucleoprotein A2/B1
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein A2/B1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22626-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Gene Ontology Terms (33)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (468)
1 – 10 of 468
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.999
Data Source: STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.999
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.999
Data Source: STRINGDB
PTBP1
Tbio
Novelty: 0.00184728
Score: 0.999
Data Source: STRINGDB
HNRNPF
Tbio
Novelty: 0.01833966
Score: 0.999
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.999
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.999
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.999
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.998
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  279.11

PubMed score by year
PubTator Score  187.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer