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Tbio
PRKACG
cAMP-dependent protein kinase catalytic subunit gamma

Protein Summary
Description
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377276
  • ENSP00000366488
  • ENSG00000165059

Symbol
  • KAPG
  • PKACg
  • BDPLT19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.93
protein domain
0.85
pathway
0.83
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (243)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Items per page:
1 – 5 of 64
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Reactome
Aquaporin-mediated transport
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
Aquaporin-mediated transport
Axon guidance
C-type lectin receptors (CLRs)
Protein-Protein Interactions (789)
1 – 10 of 789
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00534149
p_int: 1
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00372136
p_int: 0.999998219
p_ni: 0.000001781
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00763951
p_int: 0.999996905
p_ni: 0.000002833
p_wrong: 2.62e-7
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family: Enzyme
Novelty: 2
p_int: 0.99996722
p_ni: 0.000032778
p_wrong: 3e-9
Score: 0.795
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.03136062
p_int: 0.999958659
p_ni: 0.000041341
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0055702
p_int: 0.998867271
p_ni: 0.001132729
Score: 0.973
Data Source: BioPlex,STRINGDB
AKAP7
Tbio
Family: Enzyme
Novelty: 0.0577718
p_int: 0.996835277
p_ni: 0.003164721
p_wrong: 2e-9
Score: 0.823
Data Source: BioPlex,STRINGDB
GPR161
Tbio
Family: GPCR
Novelty: 0.00508196
p_int: 0.996782661
p_ni: 0.003217132
p_wrong: 2.07e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
AKAP7
Tbio
Family: Enzyme
Novelty: 0.0577718
p_int: 0.995091181
p_ni: 0.004418657
p_wrong: 0.000490162
Score: 0.823
Data Source: BioPlex,STRINGDB
AKAP1
Tbio
Family: Epigenetic
Novelty: 0.00485629
p_int: 0.994635083
p_ni: 0.005364917
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  4.81

PubMed score by year
PubTator Score  5.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer