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Tclin
FGFR3
Fibroblast growth factor receptor 3

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340107
  • ENSP00000339824
  • ENSG00000068078
  • ENST00000352904
  • ENSP00000231803
  • ENST00000412135
  • ENSP00000412903
  • ENST00000440486
  • ENSP00000414914

Symbol
  • JTK4
  • ACH
  • CEK2
  • JTK4
  • CD333
  • HSFGFR3EX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
molecular function
0.99
phenotype
0.99
cellular component
0.95


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1483.21   (req: < 5)
Gene RIFs: 359   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1483.21   (req: >= 5)
Gene RIFs: 359   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 930
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 3
VGNC:600
461067
Macaque
fibroblast growth factor receptor 3
712829
Mouse
MGI:95524
14184
Rat
RGD:620714
84489
Dog
fibroblast growth factor receptor 3
VGNC:40860
488808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor receptor 3
Macaque
fibroblast growth factor receptor 3
Mouse
Rat
Dog
fibroblast growth factor receptor 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22607-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (80)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR3
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR3
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (238)
1 – 10 of 238
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 1
Score: 0.965
Data Source: BioPlex,STRINGDB
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999986226
p_ni: 0.000010352
p_wrong: 0.000003422
Data Source: BioPlex
ALG6
Tbio
Family: Enzyme
Novelty: 0.02610188
p_int: 0.999951882
p_ni: 0.000048044
p_wrong: 7.4e-8
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999942083
p_ni: 0.000057917
Data Source: BioPlex
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.999159668
p_ni: 0.000840314
p_wrong: 1.8e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
ARRDC3
Tbio
Novelty: 0.04840692
p_int: 0.998012604
p_ni: 0.001987396
Score: 0.197
Data Source: BioPlex,STRINGDB
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.997141398
p_ni: 0.002858431
p_wrong: 1.72e-7
Score: 0.923
Data Source: BioPlex,STRINGDB
SNX11
Tdark
Novelty: 0.21586113
p_int: 0.996716055
p_ni: 0.003282312
p_wrong: 0.000001633
Score: 0.228
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.983902009
p_ni: 0.001689293
p_wrong: 0.014408697
Score: 0.181
Data Source: BioPlex,STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  1483.21

PubMed score by year
PubTator Score  1071.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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