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Tclin
KCNA4
Potassium voltage-gated channel subfamily A member 4

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any partic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328224
  • ENSP00000328511
  • ENSG00000182255

Symbol
  • KCNA4L
  • HK1
  • HBK4
  • PCN2
  • HPCN2
  • HUKII
  • KCNA8
  • KV1.4
  • KCNA4L
  • MCIDDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.93
cell type or tissue
0.74
gene perturbation
0.71
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.28   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.28   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
32.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
32.4
Pathways (5)
Neuronal System (R-HSA-112316)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (180)
1 – 10 of 180
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.991
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.987
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.985
Data Source: STRINGDB
DLGAP1
Tbio
Novelty: 0.01576595
Score: 0.84
Data Source: STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.808
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.803
Data Source: STRINGDB
KCNIP2
Tbio
Family: IC
Novelty: 0.01123517
Score: 0.801
Data Source: STRINGDB
SIGMAR1
Tclin
Novelty: 0.00338804
Score: 0.793
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  247.28

PubMed score by year
PubTator Score  104.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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