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Tbio
USF1
Upstream stimulatory factor 1

Protein Summary
Description
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368020
  • ENSP00000356999
  • ENSG00000158773
  • ENST00000368021
  • ENSP00000357000

Symbol
  • BHLHB11
  • USF
  • UEF
  • FCHL
  • MLTF
  • FCHL1
  • MLTFI
  • HYPLIP1
  • bHLHb11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.92
virus perturbation
0.9
biological process
0.88
transcription factor binding site profile
0.88
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.61   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.61   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
77.7
leukocyte count
1
1
1
75.7
monocyte percentage of leukocytes
1
1
1
55.2
granulocyte percentage of myeloid white cells
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
77.7
leukocyte count
1
75.7
monocyte percentage of leukocytes
1
55.2
granulocyte percentage of myeloid white cells
1
42.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
upstream transcription factor 1
719835
Mouse
MGI:99542
22278
Rat
RGD:620974
83586
Dog
upstream transcription factor 1
VGNC:53132
488646
Horse
upstream transcription factor 1
VGNC:50903
100066365
Species
Name
OMA
EggNOG
Inparanoid
Macaque
upstream transcription factor 1
Mouse
Rat
Dog
upstream transcription factor 1
Horse
upstream transcription factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22415-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (131)
1 – 10 of 131
USF2
Tbio
Family:  TF
Novelty:  0.00516415
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.999987143
p_ni:  0.000009519
p_wrong:  0.000003339
Data Source:  BioPlex
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
p_int:  0.999956746
p_ni:  0.000043244
p_wrong:  9e-9
Score:  0.808
Data Source:  BioPlex,STRINGDB
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.999933858
p_ni:  0.00006614
p_wrong:  2e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.991330088
p_ni:  0.008669912
Score:  0.175
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.862824148
p_ni:  0.137175852
Score:  0.415
Data Source:  BioPlex,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.962
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.955
Data Source:  STRINGDB
SP1
Tbio
Family:  TF
Novelty:  0.0007915
Score:  0.947
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.947
Data Source:  STRINGDB
Publication Statistics
PubMed Score  702.61

PubMed score by year
PubTator Score  347.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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