Tchem ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Protein Summary

Description

By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22413
• Q5T9R6
• Q9NPZ3
• Q9P1P6
• Q9UP61
• Q9Y6K3
• E-NPP 1

Gene Name

• ENPP1

Ensembl ID

• ENST00000360971
• ENSP00000354238
• ENSG00000197594
• ENST00000647893
• ENSP00000498074

Symbol

• M6S1
• NPPS
• PC1
• PDNP1
• M6S1
• NPP1
• NPPS
• PC-1
• PCA1
• ARHR2
• COLED
• PDNP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.99
protein domain	0.99
transcription factor perturbation	0.97
gene perturbation	0.9

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pyrophosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 1

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.72   (req: < 5)

Gene RIFs: 191   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.72   (req: >= 5)

Gene RIFs: 191   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0