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Tbio
GPX3
Glutathione peroxidase 3

Protein Summary
Description
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388825
  • ENSP00000373477
  • ENSG00000211445

Symbol
  • GPXP
  • GPx-P
  • GSHPx-3
  • GSHPx-P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor perturbation
0.99
disease perturbation
0.95
small molecule perturbation
0.77
disease
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.58   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.58   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Protein-Protein Interactions (115)
1 – 10 of 115
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.985
Data Source: STRINGDB
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.974
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.973
Data Source: STRINGDB
SOD3
Tbio
Family: Enzyme
Novelty: 0.0015758
Score: 0.969
Data Source: STRINGDB
GSS
Tbio
Family: Enzyme
Novelty: 0.03002278
Score: 0.94
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.919
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.887
Data Source: STRINGDB
GSTA4
Tbio
Family: Enzyme
Novelty: 0.01099229
Score: 0.871
Data Source: STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
Score: 0.864
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.849
Data Source: STRINGDB
Publication Statistics
PubMed Score  637.58

PubMed score by year
PubTator Score  321.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer