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Tbio
UBA1
Ubiquitin-like modifier-activating enzyme 1

Protein Summary
Description
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335972
  • ENSP00000338413
  • ENSG00000130985
  • ENST00000377351
  • ENSP00000366568

Symbol
  • A1S9T
  • UBE1
  • A1S9
  • A1ST
  • GXP1
  • UBE1
  • A1S9T
  • AMCX1
  • POC20
  • SMAX2
  • UBA1A
  • UBE1X
  • CFAP124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
protein complex
0.98
interacting protein
0.97
molecular function
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.43   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.43   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (454)
FGB
Tbio
Novelty:  0.00437751
p_int:  0.873915681
p_ni:  0.126084319
Score:  0.189
Data Source:  BioPlex,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.996
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.995
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.995
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.994
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.993
Data Source:  STRINGDB
CDC34
Tbio
Novelty:  0.00650407
Score:  0.992
Data Source:  STRINGDB
UBE2A
Tbio
Novelty:  0.01670792
Score:  0.989
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.988
Data Source:  STRINGDB
UBE2R2
Tbio
Novelty:  0.29593236
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin like modifier activating enzyme 1
706324
Mouse
MGI:98890
22201
Rat
RGD:1359327
314432
Dog
ubiquitin like modifier activating enzyme 1
VGNC:48036
480896
Horse
ubiquitin like modifier activating enzyme 1
VGNC:24699
100060792
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin like modifier activating enzyme 1
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 1
Horse
ubiquitin like modifier activating enzyme 1
Publication Statistics
PubMed Score 240.43
PubMed score by year
PubTator Score 120.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title