Tbio UBA1 Ubiquitin-like modifier-activating enzyme 1

Protein Summary

Description

Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22314
• Q5JRR8
• Q96E13

Gene Name

• UBA1

Ensembl ID

• ENST00000335972
• ENSP00000338413
• ENSG00000130985
• ENST00000377351
• ENSP00000366568

Symbol

• A1S9T
• UBE1
• A1S9
• A1ST
• GXP1
• UBE1
• A1S9T
• AMCX1
• POC20
• SMAX2
• UBA1A
• UBE1X
• CFAP124

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
protein complex	0.98
interacting protein	0.97
molecular function	0.96

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ubiquitin-like Modifier-activating Enzyme 1

Protein / Ligase / Ubiquitin-like Modifier-activating Enzyme 1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-like Modifier-activating Enzyme 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.32   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.32   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0