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Tchem
UGT1A1
UDP-glucuronosyltransferase 1-1

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305208
  • ENSP00000304845
  • ENSG00000241635
  • ENST00000360418
  • ENSP00000353593

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • UDPGT
  • UGT1A
  • HUG-BR1
  • BILIQTL1
  • UDPGT 1-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
drug
0.99
transcription factor perturbation
0.98
molecular function
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 818.66   (req: < 5)
Gene RIFs: 443   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 818.66   (req: >= 5)
Gene RIFs: 443   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ritonavir
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
7
7
17
99.8
circulating cell free DNA measurement
1
1
1
91.2
HIV-1 infection
1
2
2
82.2
serum metabolite measurement
1
1
3
82.2
blood metabolite measurement
1
1
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
17
99.8
circulating cell free DNA measurement
1
91.2
HIV-1 infection
2
82.2
serum metabolite measurement
3
82.2
blood metabolite measurement
2
81.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P22309-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective UGT1A1 causes hyperbilirubinemia
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glucuronidation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective UGT1A1 causes hyperbilirubinemia
Disease
Diseases of metabolism
Glucuronidation
Gene Ontology Terms (39)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (150)
1 – 10 of 150
UGT1A10
Tbio
Family: Enzyme
Novelty: 0.01535804
Score: 0.995
Data Source: STRINGDB
UGT1A8
Tbio
Family: Enzyme
Novelty: 0.00135129
Score: 0.995
Data Source: STRINGDB
UGT1A9
Tbio
Family: Enzyme
Novelty: 0.0047848
Score: 0.993
Data Source: STRINGDB
UGT1A6
Tbio
Family: Enzyme
Novelty: 0.00146917
Score: 0.993
Data Source: STRINGDB
UGT1A3
Tbio
Family: Enzyme
Novelty: 0.01005508
Score: 0.993
Data Source: STRINGDB
UGT1A4
Tbio
Family: Enzyme
Novelty: 0.00731132
Score: 0.993
Data Source: STRINGDB
UGT1A7
Tbio
Family: Enzyme
Novelty: 0.01095445
Score: 0.993
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.961
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00072521
Score: 0.939
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  818.66

PubMed score by year
PubTator Score  1150.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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