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Tchem
UGT1A1
UDP-glucuronosyltransferase 1-1

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305208
  • ENSP00000304845
  • ENSG00000241635
  • ENST00000360418
  • ENSP00000353593

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • UDPGT
  • UGT1A
  • HUG-BR1
  • BILIQTL1
  • UDPGT 1-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
drug
0.99
transcription factor perturbation
0.98
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.37   (req: < 5)
Gene RIFs: 443   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.37   (req: >= 5)
Gene RIFs: 443   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ritonavir
chemical structure image
Pathways (28)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective UGT1A1 causes hyperbilirubinemia
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glucuronidation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective UGT1A1 causes hyperbilirubinemia
Disease
Diseases of metabolism
Glucuronidation
Gene Ontology Terms (39)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (150)
1 – 10 of 150
UGT1A10
Tbio
Family: Enzyme
Novelty: 0.01786696
Score: 0.995
Data Source: STRINGDB
UGT1A8
Tbio
Family: Enzyme
Novelty: 0.00173655
Score: 0.995
Data Source: STRINGDB
UGT1A9
Tbio
Family: Enzyme
Novelty: 0.00633958
Score: 0.993
Data Source: STRINGDB
UGT1A6
Tbio
Family: Enzyme
Novelty: 0.00185202
Score: 0.993
Data Source: STRINGDB
UGT1A3
Tbio
Family: Enzyme
Novelty: 0.01316098
Score: 0.993
Data Source: STRINGDB
UGT1A4
Tbio
Family: Enzyme
Novelty: 0.00975431
Score: 0.993
Data Source: STRINGDB
UGT1A7
Tbio
Family: Enzyme
Novelty: 0.01285915
Score: 0.993
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00020884
Score: 0.961
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00095598
Score: 0.939
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018723
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  579.37

PubMed score by year
PubTator Score  1150.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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