Tchem SCP2 Non-specific lipid-transfer protein

Protein Summary

Description

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P22307
• A6NM69
• B4DGJ9
• B4DHP6
• C9JC79
• D3DQ37
• E1B6W5
• F2Z3J1
• Q15432
• Q16622
• Q5VVZ1
• Q6NXF4
• Q99430
• NSL-TP

Gene Name

• SCP2

Ensembl ID

• ENST00000371509
• ENSP00000360564
• ENSG00000116171
• ENST00000371513
• ENSP00000360568
• ENST00000371514
• ENSP00000360569
• ENST00000407246
• ENSP00000384569
• ENST00000408941
• ENSP00000386214
• ENST00000430330
• ENSP00000406636
• ENST00000435345
• ENSP00000396413
• ENST00000488965
• ENSP00000435783
• ENST00000528311
• ENSP00000434132

Symbol

• NLTP
• SCPX
• SCP-2
• SCP-X
• NSL-TP
• SCP-CHI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
molecular function	0.93
protein domain	0.92
interacting protein	0.88
cellular component	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 631.67   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 426   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 631.67   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0