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Tchem
SCP2
Non-specific lipid-transfer protein

Protein Summary
Description
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371509
  • ENSP00000360564
  • ENSG00000116171
  • ENST00000371513
  • ENSP00000360568
  • ENST00000371514
  • ENSP00000360569
  • ENST00000407246
  • ENSP00000384569
  • ENST00000408941
  • ENSP00000386214
  • ENST00000430330
  • ENSP00000406636
  • ENST00000435345
  • ENSP00000396413
  • ENST00000488965
  • ENSP00000435783
  • ENST00000528311
  • ENSP00000434132

Symbol
  • NLTP
  • SCPX
  • SCP-2
  • SCP-X
  • NSL-TP
  • SCP-CHI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.93
protein domain
0.92
interacting protein
0.88
cellular component
0.86


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.51   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 426   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.51   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL260520
chemical structure image
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sterol carrier protein 2
VGNC:1535
456862
Macaque
sterol carrier protein 2
715765
Mouse
MGI:98254
20280
Rat
RGD:3642
25541
Dog
sterol carrier protein 2
VGNC:45930
479564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sterol carrier protein 2
Macaque
sterol carrier protein 2
Mouse
Rat
Dog
sterol carrier protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22307-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Bile acid and bile salt metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Bile acid and bile salt metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (161)
1 – 10 of 161
MYO5C
Tbio
Novelty: 0.05680943
p_int: 0.915408921
p_ni: 0.084591079
Score: 0.25
Data Source: BioPlex,STRINGDB
URI1
Tbio
Family: Enzyme
Novelty: 0.04265162
p_int: 0.874410634
p_ni: 0.125589366
Score: 0.234
Data Source: BioPlex,STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
p_int: 0.788893646
p_ni: 0.211105412
p_wrong: 9.42e-7
Score: 0.289
Data Source: BioPlex,STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.995
Data Source: STRINGDB
PEX5
Tbio
Novelty: 0.00560901
Score: 0.99
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.986
Data Source: STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.985
Data Source: STRINGDB
PEX14
Tbio
Novelty: 0.0210557
Score: 0.98
Data Source: STRINGDB
ACOX2
Tbio
Family: Enzyme
Novelty: 0.02942359
Score: 0.977
Data Source: STRINGDB
HADH
Tbio
Family: Enzyme
Novelty: 0.00368073
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  583.51

PubMed score by year
PubTator Score  162.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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