IDS
Iduronate 2-sulfatase
Protein Summary
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
- ENST00000340855
- ENSP00000339801
- ENSG00000010404
- ENST00000370441
- ENSP00000359470
- ENST00000466323
- ENSP00000418264
- SIDS
- MPS2
- SIDS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.95 | ||
small molecule perturbation | 0.93 | ||
virus perturbation | 0.79 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 204.53 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 204.53 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0