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Tclin
ACHE
Acetylcholinesterase

Protein Summary
Description
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-cont ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241069
  • ENSP00000241069
  • ENSG00000087085
  • ENST00000302913
  • ENSP00000303211
  • ENST00000411582
  • ENSP00000404865
  • ENST00000412389
  • ENSP00000394976
  • ENST00000419336
  • ENSP00000403474
  • ENST00000428317
  • ENSP00000414858

Symbol
  • YT
  • ACEE
  • ARACHE
  • N-ACHE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
biological process
0.91
molecular function
0.91
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2606.49   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2606.49   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1840
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 25
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
1
1
36.2
body mass index
1
1
1
28.6
heart rate response to recovery post exercise
1
1
1
19
heart rate response to exercise
1
1
1
14.5
heel bone mineral density
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
36.2
body mass index
1
28.6
heart rate response to recovery post exercise
1
19
heart rate response to exercise
1
14.5
heel bone mineral density
1
4.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetylcholinesterase
VGNC:4245
100609296
Macaque
acetylcholinesterase (Cartwright blood group)
713370
Mouse
MGI:87876
11423
Rat
RGD:69313
83817
Dog
acetylcholinesterase
VGNC:49076
489828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetylcholinesterase
Macaque
acetylcholinesterase (Cartwright blood group)
Mouse
Rat
Dog
acetylcholinesterase
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22303-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of proteins
Neuronal System
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (182)
1 – 10 of 182
CHAT
Tchem
Family: Enzyme
Novelty: 0.00033026
Score: 0.941
Data Source: STRINGDB
CHKA
Tchem
Family: Kinase
Novelty: 0.00237839
Score: 0.92
Data Source: STRINGDB
CHKB
Tbio
Family: Kinase
Novelty: 0.00862294
Score: 0.903
Data Source: STRINGDB
GPCPD1
Tdark
Family: Enzyme
Novelty: 0.03548168
Score: 0.902
Data Source: STRINGDB
PHOSPHO1
Tchem
Family: Enzyme
Novelty: 0.05458897
Score: 0.9
Data Source: STRINGDB
COLQ
Tbio
Family: Enzyme
Novelty: 0.01414634
Score: 0.886
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.834
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.817
Data Source: STRINGDB
PRIMA1
Tbio
Novelty: 0.01886606
Score: 0.797
Data Source: STRINGDB
CHRNE
Tclin
Family: IC
Novelty: 0.01908511
Score: 0.795
Data Source: STRINGDB
Publication Statistics
PubMed Score  2606.49

PubMed score by year
PubTator Score  9029.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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