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Tbio
IL10
Interleukin-10

Protein Classes
Protein Summary
Description
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423557
  • ENSP00000412237
  • ENSG00000136634

Symbol
  • CSIF
  • TGIF
  • GVHDS
  • IL-10
  • IL10A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease
0.97
PubMedID
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23569.7   (req: < 5)
Gene RIFs: 2133   (req: <= 3)
Antibodies: 1504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23569.7   (req: >= 5)
Gene RIFs: 2133   (req: > 3)
Antibodies: 1504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.2
98
2
2
0
1.4
96.5
1
1
0
1.4
73.5
1
1
0
1.3
48.9
1
1
0
1.2
32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.2
98
0
1.4
96.5
0
1.4
73.5
0
1.3
48.9
0
1.2
32
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (174)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-12 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-10 signaling
Interleukin-12 family signaling
Gene Ontology Terms (74)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (786)
1 – 10 of 786
MTMR3
Tbio
Family: Enzyme
Novelty: 0.04961778
p_int: 0.999900584
p_ni: 0.000072577
p_wrong: 0.000026839
Data Source: BioPlex
MTMR4
Tbio
Family: Enzyme
Novelty: 0.09166984
p_int: 0.995871046
p_ni: 0.002614978
p_wrong: 0.001513975
Data Source: BioPlex
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.995323546
p_ni: 0.004676454
Score: 0.188
Data Source: BioPlex,STRINGDB
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.979830768
p_ni: 0.020169232
Data Source: BioPlex
IL10RA
Tbio
Novelty: 0.00506068
Score: 0.998
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.997
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.997
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.996
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.996
Data Source: STRINGDB
CCL2
Tchem
Novelty: 0.00010958
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  23569.70

PubMed score by year
PubTator Score  9741.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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