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Tbio
PAICS
Multifunctional protein ADE2

Protein Classes
Protein Summary
Description
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264221
  • ENSP00000264221
  • ENSG00000128050
  • ENST00000399688
  • ENSP00000382595
  • ENST00000512576
  • ENSP00000421096

Symbol
  • ADE2
  • AIRC
  • PAIS
  • ADE2
  • AIRC
  • PAIS
  • ADE2H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
molecular function
0.95
hub protein
0.94
transcription factor binding site profile
0.9


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
VGNC:2967
471236
Macaque
multifunctional protein ADE2
694743
Mouse
MGI:1914304
67054
Rat
RGD:620066
140946
Dog
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
VGNC:44243
100855769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Macaque
multifunctional protein ADE2
Mouse
Rat
Dog
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (273)
1 – 10 of 273
GART
Tclin
Novelty: 0.00524985
Score: 0.999
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.997
Data Source: STRINGDB
PPAT
Tclin
Family: Enzyme
Novelty: 0.01549862
Score: 0.996
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.994
Data Source: STRINGDB
PFAS
Tbio
Family: Enzyme
Novelty: 0.00252212
Score: 0.976
Data Source: STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.933
Data Source: STRINGDB
CHD7
Tbio
Family: Epigenetic
Novelty: 0.00065444
Score: 0.925
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.876
Data Source: STRINGDB
GLRX5
Tbio
Novelty: 0.01166161
Score: 0.861
Data Source: STRINGDB
ADSS
Tchem
Family: Enzyme
Novelty: 0.0126472
Score: 0.809
Data Source: STRINGDB
Publication Statistics
PubMed Score  354.95

PubMed score by year
PubTator Score  40.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer