Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasi ...more
- ENST00000264012
- ENSP00000264012
- ENSG00000062038
- ENST00000429102
- ENSP00000398485
- CDHP
- CDHP
- HJMD
- PCAD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
gene perturbation | 0.89 | ||
biological process | 0.82 | ||
protein domain | 0.73 | ||
biological term | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.45 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 867 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.45 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 867 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 2 | 2 | 75.3 | |||||
1 | 1 | 0 | 1.1 | 31.7 | |||||
1 | 1 | 0 | 1.1 | 27.7 | |||||
1 | 1 | 0 | 1.1 | 27.7 | |||||
1 | 1 | 0 | 1.1 | 27.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 75.3 | |||||
0 | 1.1 | 31.7 | |||||
0 | 1.1 | 27.7 | |||||
0 | 1.1 | 27.7 | |||||
0 | 1.1 | 27.6 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cadherin 3 | VGNC:8963 | 454192 | |||||
Macaque | cadherin 3 | 703324 | ||||||
Mouse | MGI:88356 | 12560 | ||||||
Rat | RGD:621089 | 116777 | ||||||
Dog | cadherin 3 | VGNC:39032 | 611010 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cadherin 3 | |||||
Macaque | cadherin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 3 | |||||
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (56)
Reactome (4)
KEGG (1)
PathwayCommons (4)
WikiPathways (47)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Gene Ontology Terms (33)
Functions (4)
Components (6)
Processes (23)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (75)
1 – 10 of 75
CTNNA3
Novelty: 0.01472452
p_int: 0.999999981
p_ni: 6e-9
p_wrong: 1.4e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
TAX1BP3
Novelty: 0.01605171
p_int: 0.999999911
p_ni: 8.4e-8
p_wrong: 5e-9
Data Source: BioPlex
PCDHGB1
Novelty: 0.60440805
p_int: 0.999999733
p_ni: 2e-9
p_wrong: 2.65e-7
Score: 0.178
Data Source: BioPlex,STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.996
Data Source: STRINGDB
JUP
Novelty: 0.0081803
Score: 0.992
Data Source: STRINGDB
CTNND1
Novelty: 0.00335459
Score: 0.986
Data Source: STRINGDB
CTNNA1
Novelty: 0.00925774
Score: 0.963
Data Source: STRINGDB
CDH1
Novelty: 0.00010629
Score: 0.942
Data Source: STRINGDB
CDH17
Novelty: 0.00035679
Score: 0.929
Data Source: STRINGDB
CDH8
Novelty: 0.04055999
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score 344.45
PubMed score by year
PubTator Score 141.13
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait