Protein Summary
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, res ...more
- ENST00000375244
- ENSP00000364393
- ENSG00000168477
- ENST00000451343
- ENSP00000407685
- ENST00000546684
- ENSP00000447694
- ENSG00000236236
- ENST00000550539
- ENSP00000448326
- ENSG00000229353
- ENST00000644971
- ENSP00000496448
- HXBL
- TNX
- TNXB1
- TNXB2
- XB
- XB
- TNX
- XBS
- EDS3
- HXBL
- TENX
- TN-X
- VUR8
- TNXB1
- TNXB2
- TNXBS
- EDSCLL
- EDSCLL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
protein domain | 0.97 | ||
phenotype | 0.79 | ||
disease | 0.75 | ||
PubMedID | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.88 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 201 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.88 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 201 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0