You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNXB
Tenascin-X

Protein Summary
Description
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375244
  • ENSP00000364393
  • ENSG00000168477
  • ENST00000451343
  • ENSP00000407685
  • ENST00000546684
  • ENSP00000447694
  • ENSG00000236236
  • ENST00000550539
  • ENSP00000448326
  • ENSG00000229353
  • ENST00000644971
  • ENSP00000496448

Symbol
  • HXBL
  • TNX
  • TNXB1
  • TNXB2
  • XB
  • XB
  • TNX
  • XBS
  • EDS3
  • HXBL
  • TENX
  • TN-X
  • VUR8
  • TNXB1
  • TNXB2
  • TNXBS
  • EDSCLL
  • EDSCLL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.97
phenotype
0.79
disease
0.75
PubMedID
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.19   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.19   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.995883473
p_ni:  0.004116502
p_wrong:  2.4e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.934
Data Source:  STRINGDB
BCAN
Tbio
Novelty:  0.00737982
Score:  0.914
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.91
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.903
Data Source:  STRINGDB
ITGA8
Tbio
Novelty:  0.0220023
Score:  0.84
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.814
Data Source:  STRINGDB
ITGA9
Tbio
Novelty:  0.01488635
Score:  0.807
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.805
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.805
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (190)
Items per page:
1 – 5 of 190
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
12
0
1.8
99.4
9
12
0
1.8
99.4
6
5
0
2.3
99
6
5
0
2.3
99
2
5
0
1.8
98.7
Items per page:
1 – 5 of 190
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
99.4
0
1.8
99.4
0
2.3
99
0
2.3
99
0
1.8
98.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1932137
81877
Dog
tenascin XB
VGNC:47704
100682877
Cow
tenascin XB
VGNC:36211
282654
Opossum
tenascin XB
100025581
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
tenascin XB
Cow
tenascin XB
Opossum
tenascin XB
Publication Statistics
PubMed Score 207.19
PubMed score by year
PubTator Score 108.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title