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Tclin
GART
Trifunctional purine biosynthetic protein adenosine-3

Protein Summary
Description
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361093
  • ENSP00000354388
  • ENSG00000159131
  • ENST00000381815
  • ENSP00000371236
  • ENST00000381831
  • ENSP00000371253
  • ENST00000381839
  • ENSP00000371261
  • ENST00000571089
  • ENSP00000459532
  • ENSG00000262473
  • ENST00000573055
  • ENSP00000459391
  • ENST00000575273
  • ENSP00000461700

Symbol
  • PGFT
  • PRGS
  • AIRS
  • GARS
  • PAIS
  • PGFT
  • PRGS
  • GARTF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein domain
1
transcription factor perturbation
1
interacting protein
0.99
disease perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.73   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.73   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1