Tbio FBL rRNA 2'-O-methyltransferase fibrillarin

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22087
• B5BUE8
• O75259
• Q6IAT5
• Q9UPI6

Gene Name

• FBL

Ensembl ID

• ENST00000221801
• ENSP00000221801
• ENSG00000105202
• ENST00000625241
• ENSP00000487390
• ENSG00000280548

Symbol

• FIB1
• FLRN
• FIB
• FLRN
• Nop1
• RNU3IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
co-expressed gene	0.89
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rrna 2'-o-methyltransferase Fibrillarin

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Rrna 2'-o-methyltransferase Fibrillarin

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Rrna 2'-o-methyltransferase Fibrillarin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658.97   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 353   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658.97   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0