Tbio FBL rRNA 2'-O-methyltransferase fibrillarin

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22087
• B5BUE8
• O75259
• Q6IAT5
• Q9UPI6

Gene Name

• FBL

Ensembl ID

• ENST00000221801
• ENSP00000221801
• ENSG00000105202
• ENST00000625241
• ENSP00000487390
• ENSG00000280548

Symbol

• FIB1
• FLRN
• FIB
• FLRN
• Nop1
• RNU3IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
co-expressed gene	0.89
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rrna 2'-o-methyltransferase Fibrillarin

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Rrna 2'-o-methyltransferase Fibrillarin

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Rrna 2'-o-methyltransferase Fibrillarin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1282.59   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 353   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1282.59   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (612)

Explore Interacting Targets

1 – 10 of 612

• See Interactions on String-DB

TGS1

Tbio

Family:  Enzyme

Novelty:  0.03390504

p_int:  0.999999986

p_ni:  1.4e-8

Score:  0.645

Data Source:  BioPlex,STRINGDB

NAP1L2

Tbio

Novelty:  0.04376067

p_int:  0.999999676

p_ni:  1.69e-7

p_wrong:  1.55e-7

Score:  0.333

Data Source:  BioPlex,STRINGDB

SRFBP1

Tbio

Novelty:  0.10070972

p_int:  0.999998091

p_ni:  0.000001909

Score:  0.185

Data Source:  BioPlex,STRINGDB

NAP1L3

Tbio

Novelty:  0.03907508

p_int:  0.999985065

p_ni:  0.000014879

p_wrong:  5.6e-8

Score:  0.295

Data Source:  BioPlex,STRINGDB

GTF3C2

Tdark

Novelty:  0.1827844

p_int:  0.999971024

p_ni:  0.000028976

Score:  0.18

Data Source:  BioPlex,STRINGDB

ZNF430

Tdark

Family:  TF

Novelty:  3.98895047

p_int:  0.999922942

p_ni:  0.000077058

Score:  0.186

Data Source:  BioPlex,STRINGDB

WDR43

Tbio

Novelty:  0.12680949

p_int:  0.999908856

p_ni:  0.000091142

p_wrong:  2e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

TERF2

Tchem

Family:  TF

Novelty:  0.01003649

p_int:  0.999689782

p_ni:  0.000310209

p_wrong:  9e-9

Score:  0.176

Data Source:  BioPlex,STRINGDB

ZNF316

Tdark

Novelty:  1.0869977

p_int:  0.999468178

p_ni:  0.000531698

p_wrong:  1.24e-7

Data Source:  BioPlex

PINX1

Tbio

Family:  TF

Novelty:  0.01237398

p_int:  0.999060618

p_ni:  0.000939382

Score:  0.835

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (5)

KEGG (1)

PathwayCommons (1)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (5)

Components (12)

Processes (6)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
histone-glutamine methyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
ATPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
TFIID-class transcription factor complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
rRNA methyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (10)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	ENSG00000280548	2	2	2		93.5
eosinophil count	EFO_0004842	ENSG00000105202	2	2	2		93.5
eosinophil percentage of leukocytes	EFO_0007991	ENSG00000105202	1	1	1		84.6
eosinophil percentage of leukocytes	EFO_0007991	ENSG00000280548	1	1	1		84.6
eosinophil percentage of granulocytes	EFO_0007996	ENSG00000280548	1	1	1		83.7

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	2		93.5
eosinophil count	EFO_0004842	2		93.5
eosinophil percentage of leukocytes	EFO_0007991	1		84.6
eosinophil percentage of leukocytes	EFO_0007991	1		84.6
eosinophil percentage of granulocytes	EFO_0007996	1		83.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Isopeptide bond
Methylation
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Ribonucleoprotein
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
Hodgkins lymphoma
neutrophil percentage of granulocytes

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	fibrillarin	VGNC:11012	456031
Mouse	fibrillarin	MGI:95486	14113
Rat	fibrillarin	RGD:1305542	292747
Dog	fibrillarin	VGNC:40748	476460
Horse	fibrillarin	VGNC:17928	100064571

Species	Name	OMA	EggNOG	Inparanoid
Chimp	fibrillarin
Mouse	fibrillarin
Rat	fibrillarin
Dog	fibrillarin
Horse	fibrillarin

Publication Statistics

PubMed Score 1282.59

PubMed score by year

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PubTator Score 77.80

PubTator score by year

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Related Publications

Text Mined References (58)

GeneRif Annotations (11)

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PMID	Year	Title