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Tbio
LPO
Lactoperoxidase

Protein Summary
Description
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection. This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262290
  • ENSP00000262290
  • ENSG00000167419
  • ENST00000421678
  • ENSP00000400245
  • ENST00000582328
  • ENSP00000464636

Symbol
  • SAPX
  • SPO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.65
cell type or tissue
0.59
pathway
0.59
kinase perturbation
0.54
molecular function
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.57   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.57   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  1
Score:  0.189
Data Source:  BioPlex,STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.719
Data Source:  STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
Score:  0.717
Data Source:  STRINGDB
LALBA
Tbio
Family:  Enzyme
Novelty:  0.00037262
Score:  0.687
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.626
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.581
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.567
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.561
Data Source:  STRINGDB
HTN3
Tbio
Novelty:  0.00825966
Score:  0.56
Data Source:  STRINGDB
NOX1
Tchem
Family:  Enzyme
Novelty:  0.0016839
Score:  0.532
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Events associated with phagocytolytic activity of PMN cells (R-HSA-8941413)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Events associated with phagocytolytic activity of PMN cells
Reactome
Immune System
Reactome
Innate Immune System
Reactome
ROS and RNS production in phagocytes
Name
Explore in Pharos
Explore in Source
Events associated with phagocytolytic activity of PMN cells
Immune System
Innate Immune System
ROS and RNS production in phagocytes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
7
8
98.6
neutrophil count
2
4
4
96.5
myeloperoxidase measurement
2
3
3
95.8
neutrophil percentage of leukocytes
2
4
5
93.4
leukocyte count
2
3
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
8
98.6
neutrophil count
4
96.5
myeloperoxidase measurement
3
95.8
neutrophil percentage of leukocytes
5
93.4
leukocyte count
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactoperoxidase
VGNC:9438
468421
Macaque
lactoperoxidase
709848
Mouse
MGI:1923363
76113
Rat
RGD:1310051
287610
Dog
lactoperoxidase
VGNC:42755
491111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactoperoxidase
Macaque
lactoperoxidase
Mouse
Rat
Dog
lactoperoxidase
Publication Statistics
PubMed Score 382.57
PubMed score by year
PubTator Score 546.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title