Protein Summary
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection. This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
- ENST00000262290
- ENSP00000262290
- ENSG00000167419
- ENST00000421678
- ENSP00000400245
- ENST00000582328
- ENSP00000464636
- SAPX
- SPO
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.65 | ||
cell type or tissue | 0.59 | ||
pathway | 0.59 | ||
kinase perturbation | 0.54 | ||
molecular function | 0.53 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 382.57 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 382.57 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (24)
1 – 10 of 24
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 1
Score: 0.189
Data Source: BioPlex,STRINGDB
CAT
Family: Enzyme
Novelty: 0.00181888
Score: 0.719
Data Source: STRINGDB
GADD45GIP1
Novelty: 0.03765684
Score: 0.717
Data Source: STRINGDB
LALBA
Family: Enzyme
Novelty: 0.00037262
Score: 0.687
Data Source: STRINGDB
CACNA1A
Family: IC
Novelty: 0.00069217
Score: 0.626
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.581
Data Source: STRINGDB
TG
Novelty: 0.00010111
Score: 0.567
Data Source: STRINGDB
CACNA1B
Family: IC
Novelty: 0.00319692
Score: 0.561
Data Source: STRINGDB
HTN3
Novelty: 0.00825966
Score: 0.56
Data Source: STRINGDB
NOX1
Family: Enzyme
Novelty: 0.0016839
Score: 0.532
Data Source: STRINGDB
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Events associated with phagocytolytic activity of PMN cells | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | ROS and RNS production in phagocytes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Events associated with phagocytolytic activity of PMN cells | ||||
Immune System | ||||
Innate Immune System | ||||
ROS and RNS production in phagocytes | ||||
Gene Ontology Terms (12)
Functions (4)
Components (4)
Processes (4)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 7 | 8 | 98.6 | |||||
neutrophil count | 2 | 4 | 4 | 96.5 | |||||
myeloperoxidase measurement | 2 | 3 | 3 | 95.8 | |||||
neutrophil percentage of leukocytes | 2 | 4 | 5 | 93.4 | |||||
leukocyte count | 2 | 3 | 3 | 93.2 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 8 | 98.6 | |||||
neutrophil count | 4 | 96.5 | |||||
myeloperoxidase measurement | 3 | 95.8 | |||||
neutrophil percentage of leukocytes | 5 | 93.4 | |||||
leukocyte count | 3 | 93.2 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lactoperoxidase | VGNC:9438 | 468421 | |||||
Macaque | lactoperoxidase | 709848 | ||||||
Mouse | MGI:1923363 | 76113 | ||||||
Rat | RGD:1310051 | 287610 | ||||||
Dog | lactoperoxidase | VGNC:42755 | 491111 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lactoperoxidase | |||||
Macaque | lactoperoxidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lactoperoxidase | |||||
Publication Statistics
PubMed Score 382.57
PubMed score by year
PubTator Score 546.31
PubTator score by year