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Tbio
PCMT1
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Protein Summary
Description
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. A ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
transcription factor perturbation
0.99
co-expressed gene
0.82
hub protein
0.79
interacting protein
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.88   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.88   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein-L-isoaspartate (D-aspartate) O-methyltransferase
VGNC:49015
463062
Macaque
protein-L-isoaspartate (D-aspartate) O-methyltransferase
695893
Mouse
MGI:97502
18537
Rat
RGD:3268
25604
Dog
protein-L-isoaspartate (D-aspartate) O-methyltransferase
476242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Macaque
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Mouse
Rat
Dog
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Protein repair
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Protein repair
Protein-Protein Interactions (108)
1 – 10 of 108
YDJC
Tbio
Family: Enzyme
Novelty: 0.19574858
p_int: 0.999999944
p_ni: 4.4e-8
p_wrong: 1.1e-8
Score: 0.217
Data Source: BioPlex,STRINGDB
DERA
Tbio
Family: Enzyme
Novelty: 0.0079635
p_int: 0.999999501
p_ni: 4.99e-7
Score: 0.254
Data Source: BioPlex,STRINGDB
ALDH16A1
Tdark
Family: Enzyme
Novelty: 0.21880567
p_int: 0.999997676
p_ni: 0.000002324
Score: 0.171
Data Source: BioPlex,STRINGDB
TMEM102
Tbio
Novelty: 0.1239857
p_int: 0.999997541
p_ni: 0.000002459
Score: 0.202
Data Source: BioPlex,STRINGDB
RMC1
Tbio
Novelty: 0.02804116
p_int: 0.999997337
p_ni: 0.000002649
p_wrong: 1.5e-8
Score: 0.212
Data Source: BioPlex,STRINGDB
RPIA
Tbio
Family: Enzyme
Novelty: 0.00968705
p_int: 0.999996678
p_ni: 0.000003298
p_wrong: 2.4e-8
Score: 0.231
Data Source: BioPlex,STRINGDB
KLHL42
Tdark
Novelty: 0.25822395
p_int: 0.999952967
p_ni: 0.000047033
Data Source: BioPlex
RAB3IP
Tbio
Novelty: 0.04046982
p_int: 0.999859324
p_ni: 0.000004253
p_wrong: 0.000136423
Score: 0.171
Data Source: BioPlex,STRINGDB
DTYMK
Tbio
Family: Kinase
Novelty: 0.00746576
p_int: 0.999779746
p_ni: 0.000220254
Score: 0.332
Data Source: BioPlex,STRINGDB
KLHL18
Tdark
Novelty: 0.52915213
p_int: 0.99960789
p_ni: 0.00039211
Data Source: BioPlex
Publication Statistics
PubMed Score  78.88

PubMed score by year
PubTator Score  58.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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