Tbio PCMT1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Protein Summary

Description

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P22061
• A8K109
• J3KP72
• Q14661
• Q16556
• Q5VYC1
• Q5VYC2
• Q93061
• Q96II9
• Q99625
• Q9BQV7
• Q9BQV8
• Q9NP03
• PIMT

Gene Name

• PCMT1

Ensembl ID

• ENST00000367378
• ENSP00000356348
• ENSG00000120265
• ENST00000367384
• ENSP00000356354
• ENST00000464889
• ENSP00000420813

Symbol

• PIMT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
transcription factor perturbation	0.99
co-expressed gene	0.82
hub protein	0.79
interacting protein	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Protein-l-isoaspartate(d-aspartate) O-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Protein-l-isoaspartate(d-aspartate) O-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 230   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.28   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0