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Tbio
OSBP
Oxysterol-binding protein 1

Protein Summary
Description
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263847
  • ENSP00000263847
  • ENSG00000110048

Symbol
  • OSBP1
  • OSBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
interacting protein
0.93
cellular component
0.89
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.48   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.48   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
31.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein
VGNC:1075
451213
Macaque
oxysterol binding protein
699325
Mouse
MGI:97447
76303
Rat
RGD:1308069
365410
Dog
oxysterol binding protein
VGNC:44149
483448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein
Macaque
oxysterol binding protein
Mouse
Rat
Dog
oxysterol binding protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22059-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Sphingolipid de novo biosynthesis
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Sphingolipid de novo biosynthesis
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (72)
1 – 10 of 72
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.999999635
p_ni:  3.65e-7
Score:  0.176
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999996585
p_ni:  0.000003415
Score:  0.992
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999942223
p_ni:  0.000057777
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.99810871
p_ni:  0.00189129
Data Source:  BioPlex
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.99170576
p_ni:  0.00829424
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.990227727
p_ni:  0.009772273
Data Source:  BioPlex
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.979328799
p_ni:  0.020671201
Score:  0.207
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.950611351
p_ni:  0.049388649
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.879469732
p_ni:  0.120530268
Data Source:  BioPlex
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.872649095
p_ni:  0.127350905
Data Source:  BioPlex
Publication Statistics
PubMed Score  257.48

PubMed score by year
PubTator Score  86.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer