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Tbio
MUT
Methylmalonyl-CoA mutase, mitochondrial

Protein Classes
Protein Summary
Description
Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274813
  • ENSP00000274813
  • ENSG00000146085

Symbol
  • MCM
  • MUT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.93
histone modification site profile
0.87
protein domain
0.85
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1102.5   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1102.5   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin measurement
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin measurement
1
32.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylmalonyl-CoA mutase
VGNC:3496
463198
Macaque
methylmalonyl-CoA mutase
706189
Mouse
MGI:97239
17850
Rat
RGD:1587662
688517
Dog
methylmalonyl-CoA mutase
VGNC:43504
474930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylmalonyl-CoA mutase
Macaque
methylmalonyl-CoA mutase
Mouse
Rat
Dog
methylmalonyl-CoA mutase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22033-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Propanoate metabolism
KEGG
Carbon metabolism
KEGG
Metabolic pathways
KEGG
Valine, leucine and isoleucine degradation
KEGG
Glyoxylate and dicarboxylate metabolism
Name
Explore in Pharos
Explore in Source
Propanoate metabolism
Carbon metabolism
Metabolic pathways
Valine, leucine and isoleucine degradation
Glyoxylate and dicarboxylate metabolism
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
TMEM184A
Tbio
Novelty: 0.16408207
p_int: 0.973183686
p_ni: 0.026816314
Score: 0.188
Data Source: BioPlex,STRINGDB
CFH
Tbio
Novelty: 0.00065547
p_int: 0.968147111
p_ni: 0.031852889
Score: 0.623
Data Source: BioPlex,STRINGDB
GRPEL2
Tdark
Novelty: 0.52660174
p_int: 0.951827959
p_ni: 0.048172041
Score: 0.687
Data Source: BioPlex,STRINGDB
CRYZ
Tbio
Family: Enzyme
Novelty: 0.00168463
p_int: 0.944545592
p_ni: 0.055454408
Score: 0.198
Data Source: BioPlex,STRINGDB
MMAA
Tbio
Novelty: 0.00965052
Score: 0.998
Data Source: Reactome,STRINGDB
MCEE
Tbio
Family: Enzyme
Novelty: 0.03190645
Score: 0.992
Data Source: STRINGDB
MMAB
Tbio
Family: Enzyme
Novelty: 0.01681296
Score: 0.958
Data Source: STRINGDB
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
Score: 0.948
Data Source: STRINGDB
SUCLA2
Tbio
Family: Enzyme
Novelty: 0.02029861
Score: 0.936
Data Source: STRINGDB
ACSF3
Tbio
Family: Enzyme
Novelty: 0.04255285
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  1102.50

PubMed score by year
PubTator Score  418.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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