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Tbio
BMP6
Bone morphogenetic protein 6

Protein Summary
Description
Induces cartilage and bone formation. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283147
  • ENSP00000283147
  • ENSG00000153162

Symbol
  • VGR
  • VGR
  • VGR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.96
gene perturbation
0.84
disease
0.77
biological term
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.59   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.59   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
2
1
30.9
95.4
forced expiratory volume
1
1
1
63.7
testosterone measurement
1
1
1
37
BMI-adjusted hip circumference
1
1
1
24.3
leukocyte count
1
1
1
24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
30.9
95.4
forced expiratory volume
1
63.7
testosterone measurement
1
37
BMI-adjusted hip circumference
1
24.3
leukocyte count
1
24
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 6
VGNC:2649
471851
Macaque
bone morphogenetic protein 6
695091
Mouse
MGI:88182
12161
Rat
RGD:2214
25644
Horse
bone morphogenetic protein 6
100033934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 6
Macaque
bone morphogenetic protein 6
Mouse
Rat
Horse
bone morphogenetic protein 6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22004-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Hippo signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Ovarian steroidogenesis
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Hippo signaling pathway
Cytokine-cytokine receptor interaction
Ovarian steroidogenesis
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (111)
1 – 10 of 111
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.988
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.986
Data Source: STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00698763
Score: 0.984
Data Source: STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
Score: 0.979
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.976
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.947
Data Source: STRINGDB
BAMBI
Tbio
Novelty: 0.00736806
Score: 0.943
Data Source: STRINGDB
HJV
Tbio
Novelty: 0.00495995
Score: 0.907
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.904
Data Source: STRINGDB
SOST
Tclin
Novelty: 0.0009273
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  539.59

PubMed score by year
PubTator Score  231

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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