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Tbio
BMP5
Bone morphogenetic protein 5

Protein Summary
Description
Induces cartilage and bone formation. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370830
  • ENSP00000359866
  • ENSG00000112175
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.78
phenotype
0.76
protein domain
0.73
cell type or tissue
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.06   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.06   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
10
97.5
2
1
0
1.1
68.5
osteoarthritis, hip
1
1
0
1.1
45.8
1
1
0
1.1
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
10
97.5
0
1.1
68.5
osteoarthritis, hip
0
1.1
45.8
0
1.1
37.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 5
VGNC:2648
462787
Macaque
bone morphogenetic protein 5
711989
Mouse
MGI:88181
12160
Rat
RGD:1305979
315824
Dog
bone morphogenetic protein 5
VGNC:38481
474944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 5
Macaque
bone morphogenetic protein 5
Mouse
Rat
Dog
bone morphogenetic protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P22003-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Hippo signaling pathway
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Hippo signaling pathway
Cytokine-cytokine receptor interaction
Protein-Protein Interactions (65)
1 – 10 of 65
HBB
Tbio
Novelty: 0.00049683
p_int: 0.993099389
p_ni: 0.006170836
p_wrong: 0.000729775
Score: 0.274
Data Source: BioPlex,STRINGDB
VWA8
Tdark
Novelty: 0.17546432
p_int: 0.928208657
p_ni: 0.071791343
Score: 0.199
Data Source: BioPlex,STRINGDB
ANKRD46
Tbio
Novelty: 0.06546845
p_int: 0.810239707
p_ni: 0.179458937
p_wrong: 0.010301356
Score: 0.187
Data Source: BioPlex,STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.981
Data Source: STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.973
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.968
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.931
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.931
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.925
Data Source: STRINGDB
SOST
Tclin
Novelty: 0.0009273
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  112.06

PubMed score by year
PubTator Score  46.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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